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Cortical circuitry supporting flexible audiovisual interactions and behaviors

支持灵活的视听交互和行为的皮质电路

基本信息

批准号：
10709755
负责人：
Andrea Rayne Hasenstaub
金额：
$ 53.82万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10709755
关键词：
Cortical circuitry supporting flexible audiovisual

项目摘要

Project Summary Interactions between the auditory and visual systems are among the most well-established cases of crossmodal interplay, yet the overwhelming bulk of the sensory physiology literature reflects studies examining processing confined to a single modality and we understand comparatively little about the circuitry mediating crossmodal interplay, or under what conditions such circuits are active. Audiovisual interactions exist even in primary auditory cortex (AC), with latencies too low to be mediated through purely top-down connections. How does this information influence sound processing? Which connections relay visual information to the auditory cortex? What are the functional consequences of these early crossmodal interactions, and what general computational principles account for interactions within this system that could extend our understanding of crossmodal processing elsewhere in the brain? Our proposal will leverage the strengths of the awake transgenic mouse model to address the core aspects of these overarching questions. We will combine translaminar recording in auditory and visual cortices of awake mice with optogenetic manipulation techniques, quantitative modeling, and behavior. We will determine how visually driven inputs affect responses, dynamics, and functional connectivity across auditory cortical layers and cell types, identify and functionally characterize circuitry relaying visual information to auditory cortex, and determine the extent to which behavioral goals modulate visual influence on auditory cortex and communication from visual to auditory cortex.

项目摘要听觉系统和视觉系统之间的相互作用是最成熟的案例之一，跨通道的相互作用，然而，绝大多数的感觉生理学文献反映了研究，处理局限于一个单一的方式，我们了解相对较少的电路介导跨模态相互作用，或在什么条件下，这种电路是活跃的。视听互动甚至存在于初级听觉皮层（AC），听觉皮层太低，无法通过纯粹的自上而下的连接进行介导。如何这些信息会影响声音处理吗？哪些连接将视觉信息传递到听觉皮质？这些早期的跨模态相互作用的功能后果是什么？计算原理解释了这个系统中的相互作用，这可以扩展我们对大脑其他地方的跨通道处理我们的提议将利用觉醒者的力量转基因小鼠模型来解决这些首要问题的核心方面。我们将联合收割机用光遗传学操作技术在清醒小鼠的听觉和视觉皮层中进行跨层记录，定量建模和行为。我们将确定视觉驱动的输入如何影响响应，动态，以及听觉皮质层和细胞类型之间的功能连接性，识别和功能表征将视觉信息传递到听觉皮层的电路，并决定行为目标调节视觉对听觉皮层的影响以及从视觉到听觉皮层的通信。