Improving Minority Health in Rheumatic Disease (IMHeaRD)

改善少数民族风湿病健康 (IMHeaRD)

• 批准号: 10709534
• 负责人: JAMES C OATES
• 金额: $ 74.5万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709534
• 关键词: ARHGEF5 gene; Address; African American population; Award; Awareness; Big Data; Biological; Biometry; Biostatistical Methods; Black race; Chronology; Clinical; Clinical Data; Clinical Research; Collaborations; Communication; Communities; Coupled; Data; Data Mart; Development; Diagnosis; Disease; Disease Progression; Education; Electronic Health Record; Electronics; Enrollment; Family; Fostering; Foundations; Frequencies; Funding; General Population; Genes; Goals; Government Agencies; Health; Health Disparities Research; Health Personnel; Health Professional; Health Promotion; Health Sciences; Hearing; Individual; Institution; Knowledge; Leadership; Link; Lupus; Medical; Mentors; Methodology; Methods; Minority; Minority Participation; Minority Recruitment; Mission; Morbidity - disease rate; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Outcome; Outcomes Research; Participant; Pathogenesis; Patient Recruitments; Patients; Peer Review; Phenotype; Pilot Projects; Productivity; Provider; Public Health; Reduce health disparities; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Rheumatism; Rheumatology; Risk; Sampling; Scleroderma; Solid; South Carolina; Systemic Lupus Erythematosus; Systemic Scleroderma; Translational Research; Trust; Universities; Woman; base; biobank; black patient; clinical care; clinical center; clinical phenotype; community engagement; forging; gene environment interaction; health data; high risk; improve minority health; improved; innovation; meetings; minority engagement; minority health; minority patient; mortality; novel; outcome disparities; patient portal; programs; recruit; sample collection; success; synergism; tool; translational study; web platform

Project Summary - Overall We wish to renew our Core Center for Clinical Research at the Medical University of South Carolina entitled Improving Minority Health in Rheumatic Diseases (IMHeaRD or IMHRD, pronounced I aM HeaRD). Its mission is to advance knowledge in clinical care and health outcomes of minority patients who have, or who are at risk of developing, systemic lupus erythematosus, scleroderma and other debilitating rheumatic diseases. The center builds on a solid framework of strong leadership in rheumatology, biostatistics, public health sciences and health disparities research coupled with trust and a proven track record of recruitment of Black patients for clinical research, particularly during the past four years, building on the success of our NIAMS P60 MCRC on Rheumatic Diseases in African Americans. IMHeaRD will retain and enhance the leadership and unique resources, including three cores: Administrative, Methodologic, and Clinical and Community Resource. We seek to impact minority health in rheumatic diseases by: a) providing well phenotyped research samples from minority lupus and scleroderma patients to an increasing pool of investigators at MUSC and elsewhere to define specific mechanisms of rheumatic disease pathogenesis and progression; b) enhancing use of the electronic health record (EHR) to identify and recruit minority participants in clinical research projects; c) developing novel methods for clinical and translational studies and studies of gene x gene and gene x environment interactions; and d) strengthening community engagement to enhance awareness of rheumatic diseases and health promotion and increase minority participation in clinical research. Our Center will offer unique resources and methods to other investigators and CCCRs. Specific aims are to: 1. Foster translational, clinical and outcomes research centered on Black patients with lupus and scleroderma; 2. Develop novel tools for using the EHR to expand enrollment and simplify recruitment of participants in clinical research; 3. Serve as a specialized resource for providing information and education about these disorders to Black patients and families, their healthcare providers, the general public, investigators and other health professionals, other CCCRs and government agencies; 4. Provide well-characterized chronologic samples and associated clinical data to help investigators identify and understand underlying biologic reasons for differences in risk profiles; 5. Deliver quantitative guidance to the CCCR Research Community while developing novel biostatistical methods and providing methodologic educational development of trainees and junior investigators ; and 6. Offer a robust pilot project program with methodologic support and mentoring for recipients. Special strengths of our center include outstanding institutional commitment, strong partnership with MUSC’s CTSA, a singular culture of trust with the community, and robust collaboration with the Lupus Foundation of America and DHHS Office of Minority Health.

项目摘要 - 总体 我们希望在南卡罗来纳州医科大学续签我们的临床研究中心 改善风湿性疾病的少数族裔健康（Imheard或Imhrd，发音我被听到）。它的使命 是为了提高患有或处于危险的少数族裔患者的临床护理和健康结果知识 发育中的系统性红斑狼疮，硬皮病和其他令人衰弱的风湿性疾病。中心 建立在风湿病，生物统计学，公共卫生科学和健康方面的坚实领导框架基础上 差异研究以及信任以及临床招募黑人患者的可靠记录 研究，特别是在过去的四年中，基于我们的NIAMS P60 MCRC的成功发展 非裔美国人的疾病。 Imheard将保留并增强领导和独特资源，包括 三个核心：行政，方法论，临床和社区资源。我们寻求影响少数派 风湿病的健康方法：a）提供少数狼疮和 硬皮病患者到MUSC和其他地方越来越多的研究人员来定义特定 风湿病发病机理和进展的机制； b）增强电子健康的使用 记录（EHR）以识别和招募临床研究项目中的少数群体参与者； c）发展小说 基因X基因和基因X环境相互作用的临床和翻译研究的方法； d）加强社区参与以提高对风湿病和健康的认识 促进并增加少数群体参与临床研究。我们的中心将提供独特的资源， 其他研究人员和CCCR的方法。具体目的是：1。寄养翻译，临床和结果 研究集中于黑人患有狼疮和硬皮病患者； 2。开发用于使用EHR的新颖工具 扩大入学率并简化临床研究参与者的招募； 3。充当专业资源 为了向黑人患者和家庭提供有关这些疾病的信息和教育，他们的医疗保健 提供者，公众，调查人员和其他卫生专业人员，其他CCCR和政府 机构； 4。提供良好的时间顺序样本和相关的临床数据，以帮助研究人员 识别并理解风险概况差异的潜在生物学原因； 5。提供定量 CCCR研究社区的指导，同时开发新型的生物统计学方法并提供 学员和初级调查人员的方法论教育发展；和6。提供一个强大的飞行员项目 具有方法论支持和心理的计划。我们中心的特殊优势包括 杰出的机构承诺，与MUSC的CTSA建立牢固的伙伴关系，这是一种与 社区，以及与美国狼疮基金会和DHHS少数民族健康办公室的强大合作。

项目成果

Unravelling the complex genetic regulation of immune cells.

• DOI: 10.1038/s41584-020-00563-1
• 发表时间: 2021-03
• 期刊: Nature reviews. Rheumatology
• 作者: Ramos PS

Development of a lupus nephritis suboptimal response prediction tool using renal histopathological and clinical laboratory variables at the time of diagnosis.

• DOI: 10.1136/lupus-2021-000489
• 发表时间: 2021-08
• 期刊: Lupus science & medicine
• 影响因子: 3.9
• 作者: Helget LN;Dillon DJ;Wolf B;Parks LP;Self SE;Bruner ET;Oates EE;Oates JC
• 通讯作者: Oates JC

Prediction models of treatment response in lupus nephritis.

• DOI: 10.1016/j.kint.2021.11.014
• 发表时间: 2022-03
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Ayoub I;Wolf BJ;Geng L;Song H;Khatiwada A;Tsao BP;Oates JC;Rovin BH
• 通讯作者: Rovin BH

Development and implementation of a virtual Lupus Patient Education Event during the COVID-19 pandemic.

• DOI: 10.1136/lupus-2021-000493
• 发表时间: 2021-03
• 期刊: Lupus science & medicine
• 影响因子: 3.9
• 作者: Maheswaranathan M;English JA;Cunningham MA;Kamen DL
• 通讯作者: Kamen DL

Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus.

• DOI: 10.1016/j.jaut.2022.102860
• 发表时间: 2022-07
• 期刊: JOURNAL OF AUTOIMMUNITY
• 影响因子: 12.8
• 作者: Ning, Wangbin;Cheng, Da;Howe, Philip H.;Bian, Chuanxiu;Kamen, Diane L.;Luo, Zhenwu;Fu, Xiaoyu;Ogunrinde, Elizabeth;Yang, Liuqing;Wang, Xu;Li, Quan-Zhen;Oates, Jim;Zhang, Weiru;White, David;Wan, Zhuang;Gilkeson, Gary S.;Jiang, Wei
• 通讯作者: Jiang, Wei