BIOMARKERS OF ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心血管疾病（CVD）是一种缓慢发展的动脉硬化，导致中风，心脏病发作和肢体血流损失。导致心绞痛（胸痛），腿部抽筋或心脏病发作的CVD只是CVD的最后阶段。疾病的早期阶段早在生命的前十年就开始开始。因此，为了减少中风和心脏病发作的患者数量，应确定处于CVD早期阶段的人进行治疗。目前的心血管疾病风险标志物只能识别60-70%的心脏病发作患者。CVD在患有狼疮（SLE）等疾病的患者中更为常见。事实上，SLE患者发生CVD的风险是普通人群的10倍。然而，在一般人群中识别早期CVD的标志物在SLE患者中不起作用。SLE患者需要CVD的早期标志物（生物标志物），以便那些有CVD风险的患者可以进行治疗以预防心脏病发作和中风。这项研究正在进行，以确定这些标志物的早期心血管疾病的系统性红斑狼疮。 这项研究由美国狼疮基金会赞助。本研究的目的是确定SLE患者心血管疾病的标志物。 受试者被要求参加这项研究，因为他们年龄在18岁至80岁之间，并已被诊断患有狼疮（SLE）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) is a slowly advancing "hardening" of the arteries that leads to strokes, heart attacks, and loss of blood flow to limbs. CVD that leads to angina (chest pain), cramping of the legs, or heart attacks is only the last phase of CVD. The early phases of disease begin as early as the first ten years of life. Therefore, to reduce the number of patients who suffer from strokes and heart attacks, people who are in the early phases of CVD should be identified for treatment. Current markers of risk for CVD identify only 60-70% of those who will later have heart attacks. CVD is much more common in patients with diseases such as lupus (SLE). In fact, the risk for CVD among patients with SLE is up to ten times that of the general population. However, markers that identify early CVD in the general population do not work as well in SLE patients. Early markers (biomarkers) of CVD are needed for SLE patients so that those at risk for CVD can have treatment to prevent heart attacks and strokes. This study is being undertaken to identify such markers of early CVD in SLE. This research is sponsored by the Lupus Foundation of America. The purpose of this study is to identify markers of CVD in patients with SLE. Subjects are being asked to participate in this study because they are between the ages of 18 and 80 and have been diagnosed with lupus (SLE).