Mechanisms responsible for hypertension caused by perinatal omega-3 fatty acid deficiency

围产期 omega-3 脂肪酸缺乏引起高血压的机制

• 批准号: nhmrc : 350313
• 负责人: A/Pr Richard Weisinger
• 金额: $ 18.71万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-responsible-hypertension-acid-deficiency/97719
• 关键词: Mechanisms; responsible; hypertension; caused; perinatal

Does the nourishment we receive as babies, or even before birth, affect our adult health? The recent findings from Barker, Meaney, Langley-Evans and their co-workers, has established that intra-uterine and early post-natal factors, particularly nutrition, influence adult neural development and cardiovascular function. It appears that the dietary intake of omega-3 fatty acids in early life may be a critical factor in the development of hypertension. We reported (Nature Medicine 2001, 7: 258-259) for the first time that the essential omega-3 fatty acid, alpha-linolenic acid (ALA), supplied in the early developmental period, affects blood pressure later in life. The work showed that moderate omega-3 fatty acid deficiency in the perinatal period resulted in hypertension, despite reversal of the deficiency at a time months before the assessment of blood pressure. These findings are suggestive of a critical period, during which time the development of normal blood pressure control mechanisms appears, at least partially, dependent upon the supply of omega-3 fatty acids. These findings suggest that omega-3 deficiency early in life may affect fatty acid metabolism, transport or uptake systems, such that re-feeding of the nutrients is functionally ineffective. Alternatively, deficiency of omega-3 fatty acids early in life may arrest development of one or more of the key signalling pathways in the control of blood pressure, such as the Brain Angiotensin System. The influence of dietary omega-3 fatty acid supply, relative to the critical period, on expression of genes involved in the control of blood pressure as well as in fatty acid metabolism, will be defined. Also, the role of the brain angiotensin system in omega-3 fatty acid deficiency-induced hypertension will be determined. We expect that the results of this study will profoundly affect hypertension research, as well as nutrition, particularly that for infants.

我们在婴儿时期，甚至在出生前接受的营养，会影响我们成年后的健康吗？Barker、Meaney、Langley-Evans和他们的同事最近的研究结果表明，子宫内和出生后早期的因素，特别是营养，会影响成年人的神经发育和心血管功能。看来，在生命早期从饮食中摄入欧米茄-3脂肪酸可能是高血压发展的关键因素。我们首次报道了（Nature Medicine 2001，7：258-259）在早期发育期提供的必需ω-3脂肪酸，α-亚麻酸（ALA），在以后的生活中影响血压。这项工作表明，在围产期中度ω-3脂肪酸缺乏导致高血压，尽管在血压评估前几个月的时间逆转的不足。这些发现提示了一个关键时期，在此期间，正常血压控制机制的发展似乎至少部分依赖于omega-3脂肪酸的供应。这些发现表明，生命早期的omega-3缺乏可能会影响脂肪酸代谢，运输或吸收系统，因此重新喂养营养素在功能上无效。另外，在生命早期缺乏ω-3脂肪酸可能会阻止一个或多个控制血压的关键信号通路的发展，如脑血管紧张素系统。将确定饮食ω-3脂肪酸供应相对于关键期对参与血压控制以及脂肪酸代谢的基因表达的影响。此外，脑血管紧张素系统在ω-3脂肪酸缺乏引起的高血压中的作用也将被确定。我们希望这项研究的结果将深刻影响高血压研究，以及营养，特别是婴儿的营养。