Adaptive Sensorimotor Control in Children with DCD

DCD 儿童的自适应感觉运动控制

• 批准号: 7077646
• 负责人: Jane E. Clark
• 金额: $ 29.94万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7077646
• 关键词: academic achievement; behavior test; body physical activity; child (0-11); clinical research; disease /disorder; mood disorders; perception disorder; posture; psychomotor function; sensorimotor system; sensory disorders; space perception; visual perception

DESCRIPTION (provided by applicant): The long-term objective of this research program is to understand the underlying mechanisms of Developmental Coordination Disorder (DCD) and to provide a scientific basis for the evaluation, and interventions of children with this disorder. In elementary school, children with DCD are estimated to comprise up to 6 percent of the population (APA, 1994). These children are at risk for poor academic achievement, socio-emotional difficulties, and long-term health problems due to their lack of participation in physical activities. Previous work on children with DCD has focused primarily on perceptual or task deficits. This proposal examines the hypothesis that children with DCD have problems with the relationship between perception and action and more specifically with the ability to adapt this relationship to new environments and tasks (referred to as adaptive sensorimotor control). In this project, we combine behavioral and computational approaches to investigate this relationship in 7-year-old children with and without DCD in stable and changing sensorimotor environments. Four experimental paradigms are used (a visuomotor drawing task, two postural tasks, one with a driving visual stimulus and another with a driving somatosensory stimulus, and an auditory bilateral tapping task). Thus, we examine the children across multiple motor tasks (drawing, posture, tapping), varying modalities (visual, touch, auditory), and varying time-scales (real-time, short-term adaptation or learning and developmental-time). Such experimental variations are included to address the issue of heterogeneity in this population and more specifically the claim that there are subtypes of DCD that may be task and/or modality dependent for identification. The specific aims of this proposal are to behaviorally and computationally: 1) Characterize the sensorimotor relationships across four tasks. We hypothesize that children with DCO will have less well-defined sensorimotor deficits in all tasks as indexed by measures of spatial and temporal accuracy and variability. Individually, children with DCD will show differential sensorimotor deficits across tasks indicative of the heterogeneity (and possible subtypes) of this population. 2) Investigate the learning of novel internal models under gradual and step-like changes in sensorimotor relationships across four tasks. We hypothesize that children with DCD will be less able to adapt to changes as indexed by time-course, spatial and temporal accuracy and variability measures. Individually, children with DCD will demonstrate differential effects with the abrupt and gradual changes reflecting different underlying mechanisms. 3) Investigate sensorimotor switching across four tasks. We hypothesize that children with DCD will demonstrate an averaging between sensorimotor relationships and/or take longer to stabilize their sensorimotor performance after experiencing a second novel sensorimotor relationship. And 4) Characterize the developmental changes in sensorimotor relationships and adaptations across four tasks after two years. We hypothesize that children with DCD will continue to show broad and non-adaptive sensorimotor tuning as indexed by measures in experiments related to specific aims #1 -3. Taken together, the information from these specific aims will lay the groundwork for future intervention studies as well as further investigation into the underlying mechanisms of this movement disorder.

描述（申请人提供）：该研究项目的长期目标是了解发育协调障碍（DCD）的潜在机制，并为患有该障碍的儿童的评估和干预提供科学依据。在小学，患有发展性协调障碍 (DCD) 的儿童估计占总人口的 6%（APA，1994）。由于缺乏体育活动的参与，这些儿童面临学业成绩不佳、社会情感困难和长期健康问题的风险。之前针对发展性协调障碍儿童的研究主要集中在知觉或任务缺陷上。该提案检验了这样的假设：患有发展性协调障碍的儿童在感知和行动之间的关系方面存在问题，更具体地说，在使这种关系适应新环境和任务的能力方面存在问题（称为适应性感觉运动控制）。在这个项目中，我们结合行为和计算方法来研究患有和不患有 DCD 的 7 岁儿童在稳定和变化的感觉运动环境中的这种关系。使用四种实验范例（一个视觉运动绘图任务、两个姿势任务，一个具有驱动视觉刺激，另一个具有驱动体感刺激，以及听觉双边敲击任务）。因此，我们检查儿童的多种运动任务（绘画、姿势、敲击）、不同的模式（视觉、触觉、听觉）和不同的时间尺度（实时、短期适应或学习和发展时间）。包括此类实验变化是为了解决该群体中的异质性问题，更具体地说，是为了解决 DCD 亚型可能依赖于任务和/或模式进行识别的问题。该提案的具体目标是在行为和计算上：1）表征四个任务之间的感觉运动关系。我们假设患有 DCO 的儿童在所有任务中都存在不太明确的感觉运动缺陷，如空间和时间准确性和变异性测量所索引的。就个体而言，患有发展性协调障碍的儿童在不同的任务中会表现出不同的感觉运动缺陷，这表明该人群的异质性（以及可能的亚型）。 2）研究在四项任务中感觉运动关系逐渐和阶梯式变化下新的内部模型的学习。我们假设患有 DCD 的儿童适应时间进程、空间和时间准确性以及变异性指标所指示的变化的能力较差。就个体而言，患有发展性协调障碍的儿童会表现出不同的影响，突然和渐进的变化反映了不同的潜在机制。 3) 研究四项任务之间的感觉运动切换。我们假设患有 DCD 的儿童在经历第二次新的感觉运动关系后，会表现出感觉运动关系之间的平均和/或需要更长的时间来稳定他们的感觉运动表现。 4) 描述两年后四项任务中感觉运动关系和适应的发展变化。我们假设患有 DCD 的儿童将继续表现出广泛的、非适应性的感觉运动调节，如与特定目标 #1 -3 相关的实验中的测量指标所示。总而言之，来自这些具体目标的信息将为未来的干预研究以及进一步调查这种运动障碍的潜在机制奠定基础。

项目成果

Statistically characterizing intra- and inter-individual variability in children with Developmental Coordination Disorder.

• DOI: 10.1016/j.ridd.2010.12.043
• 发表时间: 2011-07
• 期刊: Research in developmental disabilities
• 影响因子: 3.1
• 作者: King BR;Harring JR;Oliveira MA;Clark JE
• 通讯作者: Clark JE

Auditory-motor integration of subliminal phase shifts in tapping: better than auditory discrimination would predict.

• DOI: 10.1007/s00221-014-3837-9
• 发表时间: 2014-04
• 期刊: EXPERIMENTAL BRAIN RESEARCH
• 影响因子: 2
• 作者: Kagerer, Florian A.;Viswanathan, Priya;Contreras-Vidal, Jose L.;Whitall, Jill
• 通讯作者: Whitall, Jill

Development of interactions between sensorimotor representations in school-aged children.

学龄儿童感觉运动表征之间相互作用的发展。

• DOI: 10.1016/j.humov.2014.02.001
• 发表时间: 2014-04
• 期刊: HUMAN MOVEMENT SCIENCE
• 影响因子: 2.1
• 作者: Kagerer, Florian A.;Clark, Jane E.
• 通讯作者: Clark, Jane E.

Continuous and discontinuous drawing: high temporal variability exists only in discontinuous circling in young children.

• DOI: 10.3200/jmbr.40.5.391-399
• 发表时间: 2008-09
• 期刊: Journal of motor behavior
• 影响因子: 1.4
• 作者: Bo J;Bastian AJ;Contreras-Vidal JL;Kagerer FA;Clark JE
• 通讯作者: Clark JE

Development of kinesthetic-motor and auditory-motor representations in school-aged children.

学龄儿童动觉运动和听觉运动表征的发展。

• DOI: 10.1007/s00221-015-4288-7
• 发表时间: 2015
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Kagerer,FlorianA;Clark,JaneE
• 通讯作者: Clark,JaneE