Hot Flashes and Neurovascular Function in Women

女性潮热与神经血管功能

基本信息

  • 批准号:
    10714724
  • 负责人:
  • 金额:
    $ 5.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). As such, the overall goal of this application is to determine autonomic neurovascular function in midlife women with and without vasomotor symptoms (hot flashes). For the purposes of this application we will define neurovascular function as a concept that encompasses sympathetic outflow, the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic properties of the vascular endothelium and smooth muscle. It is thus related to the regulation of tissue blood flow. In this context, neurovascular function is critically important to women’s health and aging. Aim 1 will compare microvascular function in women with objectively assessed low and high frequency hot flashes. Aim 2 will determine autonomic function and reactivity in women with objectively assessed low and high frequency hot flashes. Finally, Aim 3 will characterize cerebrovascular function in women with objectively assessed low and high frequency hot flashes. Importantly, this work will provide the first comprehensive and mechanistic evaluation of autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus, the Applicant’s long-term goal is to develop interventions to reduce the incidence of cardiovascular disease in women with hot flashes. The proposed studies will build on the Applicant’s previous training and the mentorship team, formal course work on running clinical trials, and technical training plan will provide opportunities to gain additional knowledge in a new area and learn new experimental techniques and approaches. Finally, this work will generate an investigative niche that will complement the Applicant’s intellectual and technical skills that will facilitate the launch of her independent career.
项目总结/文摘

项目成果

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Sarah Elizabeth Baker其他文献

Sarah Elizabeth Baker的其他文献

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{{ truncateString('Sarah Elizabeth Baker', 18)}}的其他基金

Hot Flashes and Neurovascular Function in Women
女性潮热与神经血管功能
  • 批准号:
    10598449
  • 财政年份:
    2021
  • 资助金额:
    $ 5.4万
  • 项目类别:
Hot Flashes and Neurovascular Function in Women
女性潮热与神经血管功能
  • 批准号:
    10358626
  • 财政年份:
    2021
  • 资助金额:
    $ 5.4万
  • 项目类别:
Hot Flashes and Neurovascular Function in Women
女性潮热与神经血管功能
  • 批准号:
    10213394
  • 财政年份:
    2021
  • 资助金额:
    $ 5.4万
  • 项目类别:
Improving Drug Delivery In Individuals With Cystic Fibrosis Using Exercise
通过运动改善囊性纤维化患者的药物输送
  • 批准号:
    9360557
  • 财政年份:
    2016
  • 资助金额:
    $ 5.4万
  • 项目类别:
Improving Drug Delivery In Individuals With Cystic Fibrosis Using Exercise
通过运动改善囊性纤维化患者的药物输送
  • 批准号:
    9047696
  • 财政年份:
    2016
  • 资助金额:
    $ 5.4万
  • 项目类别:

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