AIDS-related Animal Services Building Cage Washing Facility

艾滋病相关动物服务大楼笼子清洗设施

• 批准号: 7242165
• 负责人: M. SUSAN SMITH
• 金额: $ 53.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-21 至 2009-05-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7242165
• 关键词: 15 year old; Acquired Immunodeficiency Syndrome; Animal Welfare; Animals; Appendix; Applications Grants; Area; Back; Commit; Communicable Diseases; Complex; Containment; Deterioration; Disease; Employee; Equipment; Floor; Funding; Genus Lynx; Grant; Growth; Guidelines; HIV; Housing; Infectious Agent; Macaca mulatta; Mechanics; Modeling; Numbers; Population; Procedures; Recommendation; Regulation; Request for Proposals; Research; Research Personnel; Research Project Grants; Resources; Risk; Running; SIV; Sanitation; Services; Side; Site; Sterilization for infection control; Support of Research; Surface; System; United States National Institutes of Health; Virus; West Nile virus; Workplace; animal care; behavior test; cost; day; design; improved; nonhuman primate; prevent; programs; vaccine development

DESCRIPTION (provided by applicant): This proposal requests funds to renovate the old cage washing facility in the original part of the Animal Services Building (ASB) complex that houses nonhuman primates (NHPs). Our objectives are to provide outstanding animal care for NHPs by maintaining the highest levels of sanitation and complying with USDA regulations and AAALAC guidelines. The need to renovate the old cage wash facility is driven by growing research programs at ONPRC. Much of this growth has been in AIDS-related and other infectious disease projects. To support these projects, the ONPRC has greatly expanded its SPF and expanded SPF-lndian-origin rhesus macaque populations. An increase in cage wash sanitation capabilities will insure successful growth of this valuable colony while preventing contamination of viruses that confound AIDS-related research. In addition, most of the NHPs involved in AIDS-related research are housed in the original part of the ASB and are dependent on the old cage washing facility for NHP cage sterilization and sanitation. This facility has been in service for over 15 years, and it has had increasing use as the number of animals assigned to projects has increased and as the ASB complex has expanded. Fifteen years of very heavy use have resulted in significant deterioration of all mechanical systems of the cage washer. There have been numerous mechanical malfunctions in the last 4 years, resulting in very poor reliability. Thus, a new cage washer is a critical piece of equipment that would provide reliable service for at least another 15-20 years. In addition, the old cage washer is only a single-sided machine, which limits the through-put of cages and restricts the number of animals that can be housed in the ASB without running additional shifts. The proposed purchase of a new, more reliable cage washer that has double the capacity of the current 15-year-old machine would allow ONPRC to continue to expand the use of NHPs, provide back-up capabilities for other cage washers, facilitate compliance with USDA regulations that require cage sanitation at least every 2weeks, and conserve natural and financial resources through improved operating efficiency. We also propose to refurbish drains and wall and floor surfaces throughout the cage washing facility; these upgrades will improve room sanitation levels, create durable finishes that will insure USDA compliance for the long-term, improve efficiency, and provide for a much safer work environment for employees. The following aims are proposed in this grant: Specific Aim 1: Purchase a Lynx Model 450LX Rack and Cage Washer, double wide. Specific Aim 2: Remodel the site for installation of the double-wide cage washer and refurbish the drains, floors and walls throughout the cage washing facility.

描述（由申请人提供）： 该提案要求资金翻新装有非人类灵长类动物（NHP）的动物服务大楼（ASB）综合体的原始部分（ASB）的原始部分。我们的目标是通过维持最高水平的卫生设施并遵守USDA法规和AAALAC指南，为NHP提供出色的动物护理。翻新旧笼子清洗设施的需求是由ONPRC不断增长的研究计划驱动的。这种增长大部分都是与艾滋病有关的和其他传染病项目。为了支持这些项目，ONPRC大大扩展了其SPF，并扩大了SPF-LNDIAN-ORIGIN恒河猕猴的种群。笼子清洗卫生能力的提高将确保这种有价值的菌落的成功增长，同时防止污染与艾滋病相关研究的病毒。此外，大多数参与艾滋病相关研究的NHP都容纳在ASB的原始部分，并依赖于用于NHP笼灭菌和卫生设施的旧笼式洗涤设施。 该设施已经服务了15年以上，并且随着分配给项目的动物数量的增加，并且随着ASB综合体的扩大，它已经越来越多。十五年的非常大量的使用导致笼垫圈的所有机械系统显着恶化。在过去的四年中，机械故障发生了许多，导致可靠性差。因此，新的笼子洗衣机是一项关键的设备，将至少再提供15 - 20年的可靠服务。此外，旧的笼子洗衣机只是单面机器，它限制了笼子的贯穿笼子，并限制了可以在ASB中容纳的动物数量，而无需运行其他偏移。提议购买一种新的，更可靠的笼垫圈，该清洗机的容量是现有15年历史的机器的两倍，它将允许ONPRC继续扩大NHP的使用，为其他笼垫机提供备用功能，从而促进USDA法规，以符合USDA规定，这些法规至少需要每2周，并通过提高的运营效率提高了自然和财务资源。 我们还建议在整个笼子清洗设施中翻新排水沟，墙壁和地板表面；这些升级将提高房间的卫生水平，创造耐用的饰面，从而确保USDA的长期合规性，提高效率，并为员工提供更安全的工作环境。这笔赠款提出了以下目的： 特定目标1：购买lynx型号450lx架子和笼子垫圈，双宽。 具体目标2：重塑安装双宽笼垫圈的站点，并在整个笼子清洗设施中翻新排水沟，地板和墙壁。