AIDS-related Animal Services Building Cage Washing Facility

艾滋病相关动物服务大楼笼子清洗设施

• 批准号: 7242165
• 负责人: M. SUSAN SMITH
• 金额: $ 53.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-21 至 2009-05-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7242165
• 关键词: 15 year old; Acquired Immunodeficiency Syndrome; Animal Welfare; Animals; Appendix; Applications Grants; Area; Back; Commit; Communicable Diseases; Complex; Containment; Deterioration; Disease; Employee; Equipment; Floor; Funding; Genus Lynx; Grant; Growth; Guidelines; HIV; Housing; Infectious Agent; Macaca mulatta; Mechanics; Modeling; Numbers; Population; Procedures; Recommendation; Regulation; Request for Proposals; Research; Research Personnel; Research Project Grants; Resources; Risk; Running; SIV; Sanitation; Services; Side; Site; Sterilization for infection control; Support of Research; Surface; System; United States National Institutes of Health; Virus; West Nile virus; Workplace; animal care; behavior test; cost; day; design; improved; nonhuman primate; prevent; programs; vaccine development

DESCRIPTION (provided by applicant): This proposal requests funds to renovate the old cage washing facility in the original part of the Animal Services Building (ASB) complex that houses nonhuman primates (NHPs). Our objectives are to provide outstanding animal care for NHPs by maintaining the highest levels of sanitation and complying with USDA regulations and AAALAC guidelines. The need to renovate the old cage wash facility is driven by growing research programs at ONPRC. Much of this growth has been in AIDS-related and other infectious disease projects. To support these projects, the ONPRC has greatly expanded its SPF and expanded SPF-lndian-origin rhesus macaque populations. An increase in cage wash sanitation capabilities will insure successful growth of this valuable colony while preventing contamination of viruses that confound AIDS-related research. In addition, most of the NHPs involved in AIDS-related research are housed in the original part of the ASB and are dependent on the old cage washing facility for NHP cage sterilization and sanitation. This facility has been in service for over 15 years, and it has had increasing use as the number of animals assigned to projects has increased and as the ASB complex has expanded. Fifteen years of very heavy use have resulted in significant deterioration of all mechanical systems of the cage washer. There have been numerous mechanical malfunctions in the last 4 years, resulting in very poor reliability. Thus, a new cage washer is a critical piece of equipment that would provide reliable service for at least another 15-20 years. In addition, the old cage washer is only a single-sided machine, which limits the through-put of cages and restricts the number of animals that can be housed in the ASB without running additional shifts. The proposed purchase of a new, more reliable cage washer that has double the capacity of the current 15-year-old machine would allow ONPRC to continue to expand the use of NHPs, provide back-up capabilities for other cage washers, facilitate compliance with USDA regulations that require cage sanitation at least every 2weeks, and conserve natural and financial resources through improved operating efficiency. We also propose to refurbish drains and wall and floor surfaces throughout the cage washing facility; these upgrades will improve room sanitation levels, create durable finishes that will insure USDA compliance for the long-term, improve efficiency, and provide for a much safer work environment for employees. The following aims are proposed in this grant: Specific Aim 1: Purchase a Lynx Model 450LX Rack and Cage Washer, double wide. Specific Aim 2: Remodel the site for installation of the double-wide cage washer and refurbish the drains, floors and walls throughout the cage washing facility.

描述(由申请人提供)： 这项提案要求资金翻新动物服务大楼(ASB)建筑群(ASB)原有部分的旧笼子清洗设施，那里容纳了非人类灵长类动物(HHP)。我们的目标是通过保持最高水平的卫生设施，并遵守美国农业部的规定和AAALAC指南，为NHP提供出色的动物护理。翻新旧的笼子清洗设施的需要是由ONPRC不断增长的研究计划推动的。这一增长的很大一部分来自与艾滋病相关的项目和其他传染病项目。为了支持这些项目，ONPRC大大扩大了SPF，并扩大了SPF-印度原生恒河猴种群。笼子清洗卫生能力的提高将确保这一宝贵群体的成功增长，同时防止混淆艾滋病相关研究的病毒污染。此外，参与艾滋病相关研究的大多数国家卫生保健计划被安置在ASB的原始部分，依靠旧的笼子清洗设施进行NHP笼子消毒和卫生。 这个设施已经投入使用超过15年，随着分配给项目的动物数量的增加和ASB综合体的扩大，它的使用也越来越多。15年来的大量使用已导致笼式垫圈的所有机械系统严重损坏。在过去的4年里，发生了许多机械故障，导致可靠性非常差。因此，新的笼式垫圈是一种关键的设备，可以提供至少15-20年的可靠服务。此外，旧的笼式洗衣机只是一台单面机，限制了笼子的吞吐量，限制了ASB中可以容纳的动物数量，而不需要额外运行班次。拟议购买一台新的、更可靠的笼式垫圈，其容量是目前已有15年历史的机器的两倍，这将使ONPRC能够继续扩大NHP的使用，为其他笼式垫圈提供备用能力，促进遵守美国农业部要求至少每两周进行一次笼子卫生的规定，并通过提高运营效率来节约自然和财政资源。 我们还提议整修整个笼式洗涤设施的排水沟、墙面和地板；这些升级将提高房间卫生水平，创造耐用的饰面，确保长期遵守美国农业部的规定，提高效率，并为员工提供更安全的工作环境。在这笔赠款中提出了以下目标： 具体目标1：购买一台Lynx型号450LX机架和笼式垫圈，双宽。 具体目标2：改造安装双宽笼式洗涤器的场地，整修整个笼式洗涤设施的排水沟、地板和墙壁。