CONTROL OF GONADOTROPIN SECRETION DURING LACTATION

哺乳期间促性腺激素分泌的控制

• 批准号: 7715863
• 负责人: M. SUSAN SMITH
• 金额: $ 5.55万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715863
• 关键词: Amenorrhea; Anorexia Nervosa; Bulimia; Chronic; Computer Retrieval of Information on Scientific Projects Database; Condition; Controlled Study; Eating; Electrophysiology (science); Exercise; Funding; Gonadotropin Hormone Releasing Hormone; Gonadotropins; Grant; Hyperphagia; Hypothalamic structure; Institution; Insulin; Lactation; Leptin; Macaca mulatta; Malnutrition; Milk; Neurons; Neuropeptides; Numbers; Obesity; Periodicity; Physiological; Production; Rattus; Research; Research Personnel; Resources; Signal Transduction; Source; Study models; System; United States National Institutes of Health; Woman; base; energy balance; feeding; hypocretin; melanin-concentrating hormone; relating to nervous system; reproductive; reproductive function; restoration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lactation is characterized by an inhibition of reproductive cyclicity due to a suppression of gonadotropin releasing hormone (GnRH), excessive hyperphagia and negative energy balance due to milk production. The central hypothesis of this proposal is that suppression of GnRH/LH secretion is due to suckling-induced alterations in hypothalamic neural systems that regulate food intake and energy balance. Our studies have recently established that several hypothalamic neuropeptide orexigenic systems involved in regulating food intake/energy balance (NPY, orexin, melanin concentrating hormone) make direct connections with GnRH neurons, thus providing a neuroanatomical framework by which signals denoting changes in food intake/energy balance can be directly transmitted to GnRH neurons. We have also found changes in a number of substances that reflect the negative energy balance (suppressed leptin, insulin) and are likely to be involved in the chronic hyperphagia during lactation, a condition similar to obesity. Current studies are using hypothalamic explants and electrophysiology to determine if NPY, orexin or melanin concentrating hormone have direct inhibitory effects on GnRH neurons. Studies are also restoring leptin and insulin to postlactation levels and determining the effects on hypothalamic neuropeptide feeding systems and on restoration of GnRH/LH secretion. The interaction between reproductive function and energy balance during lactation provides a physiological model for studying a number of conditions in women (undernutrition, anorexia nervosa, bulimia and exercise-induced amenorrhea) that involve a suppression of reproductive function associated with changes in energy balance. The results of the studies in the rat formed the basis of a new funded project to study control of food intake in the rhesus monkey.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 哺乳化的特征是由于促性腺激素释放激素（GNRH），过度镀膜和由于牛奶产生而导致的负能量平衡，抑制了生殖环节性。该提案的中心假设是，抑制GnRH/LH分泌是由于哺乳诱导的下丘脑神经系统的改变引起的调节食物摄入量和能量平衡的改变。我们的研究最近确定，几种参与调节食物摄入/能量平衡（NPY，OREXIN，黑色素浓缩激素）的下丘脑神经肽的原始系统与GNRH神经元建立了直接连接，从而可以通过表达对食物进型/能量平衡的指示性的变化可以使神经融合框架直接跨性别transins transs transits transits transins transmits gn。我们还发现，许多反映负能量平衡（抑制瘦素，胰岛素）的物质的变化，并且在泌乳过程中可能参与慢性心phagia，这种状况与肥胖类似。当前的研究使用下丘脑外植体和电生理学来确定NPY，Orexin或黑色素浓缩激素是否对GNRH神经元具有直接的抑制作用。研究还将瘦素和胰岛素恢复到腔内水平，并确定对下丘脑神经肽喂养系统的影响以及对GNRH/LH分泌的恢复。泌乳期间生殖功能与能量平衡之间的相互作用为研究女性的多种疾病（营养不良，神经性厌食症，贪食症和运动诱导的闭经）提供了生理模型，涉及抑制与能量平衡变化相关的生殖功能。大鼠研究的结果构成了一个新资助的项目的基础，以研究恒河猴食物摄入量的控制。