The Pacific Ocean Native Observational (PONO) Health Legacy Study

太平洋原住民观测 (PONO) 健康遗产研究

• 批准号: 10724217
• 负责人: Marjorie K. Leimomi Mala Mau
• 金额: $ 58.37万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724217
• 关键词: Address; Age; Age Years; Age of Onset; Asian Americans; Behavior; Behavioral; Biological; Biological Factors; Blood; Body mass index; Cardiopulmonary; Cardiovascular Diseases; Cause of Death; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinic Visits; Clinical; Clinical Research; Cohort Studies; Collaborations; Communities; Complex; Data; Data Reporting; Diabetes Mellitus; Diet; Disease; Disease Outcome; Disparity; Electronic Health Record; Enrollment; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Epidemiology; Ethnic Origin; Family; Feces; Federally Qualified Health Center; Future Generations; Generations; Genetic; Glycosylated hemoglobin A; Goals; Hawaii; Health; Health Disparities Research; Health behavior; Heterogeneity; Home; Household; Immunologics; Incidence; Individual; Inflammation; Institutional Racism; Intervention Studies; Investments; Knowledge; Life Style; Longevity; Longitudinal Studies; Measures; Mediating; Medical; Metabolic; Metabolic Diseases; Methodology; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Outcome; Outcome Measure; Pacific Islander; Pacific Ocean; Participant; Periodicals; Persons; Phase; Physical activity; Population; Prevalence; Process; Protocols documentation; Pulmonary Heart Disease; Questionnaires; Race; Recording of previous events; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Sample Size; Severities; Smoking; Social Network; Technology; Testing; Time; Tissues; Trauma; Universities; Urine; Variant; Visceral; Visit; Work; age group; biobank; blood-based biomarker; cohort; community engagement; community organizations; data standards; diabetes risk; early onset; epigenomics; ethnic diversity; follow-up; gene environment interaction; health disparity; health inequalities; immune function; innovation; microbiome; mortality; multi-racial; novel; population based; prospective; psychosocial; racial population; recruit; resilience factor; sample collection; sex; social; social health determinants; socioenvironmental factor

PROJECT SUMMARY Hawai‘i is the most ethnically diverse state in the US. Native Hawaiians (NH), Pacific Islanders (PI) and Asian Americans (AsA) account for nearly 70% of the state’s population & it is home to >50% of all NHPI in the US. This UG3/UH3 proposal will establish a new prospective, multi-generational cohort to investigate cardiopulmonary & metabolic (CPM) health among NH & Micronesian PI in Hawai‘i. These 2 distinct, yet understudied, sub-populations have an excess burden of CPM disease outcomes. Diabetes mellitus (DM) occurs in 28% and preDM in 37% of NHPI (>20y.o.), suggesting >50% of NHPI have or are at-risk for DM. CVD mortality is 4-fold higher in NHPI with DM compared with nonDM. CVD mortality is the leading cause of death among NHPI. Despite decades of clinical & intervention studies among NHPI, CPM health inequities remain largely unchanged & is increasing among younger NH and PI people. Our proposal, the Pacific Ocean Native Observational (PONO) Health Legacy Study, will directly confront methodological challenges (i.e. racial aggregation, small sample size, etc.) of prior NHPI studies & will conduct innovative, technology-driven “populomics” approaches to change the course of CPM health disparities among NH & PI. Our approach builds on a strong interdisciplinary team of scientific & community-based leaders who bring decades of community, clinical, epidemiological & epigenomic expertise. We will work closely with the Coordinating Center to maximize the overall AsA-NHPI cohort’s ability to conduct studies of multiple hypotheses testing. Our specific aims (S.A.) are as follows: S.A.#1 (UG3): Establish a prospective, community-engaged, multi-generational population-based cohort study of 2,500 Native Hawaiians and Pacific Islanders in Hawai‘i. Our longstanding partnerships with clinical & community-based groups are primed & enthusiastic to recruit, retain & conduct standardized data & biological specimen collection that will invest in the health of future generations. S.A. #2 (UH3): Characterize the relationship of risk and resilience factors with clinical blood-based biomarkers of metabolic and immunologic function relevant to CPM conditions. Determine prevalence of CPM subclinical disease & conduct association studies of multi-level risk & resilience factors by CPM conditions. S.A. #3 (UH3): Assess the impact of CPM-associated risk and resilience factors on incident CPM- outcomes measured over time between Hawai‘i and continental populations of NH and PI in the AsA- NHPI cohort study. Determine incidence of CPM outcomes associated with multi-level risk/resilience factors & to compare data with relevant subpopulations in the overall AsANHPI cohort. The overall impact of the PONO study is its potential to transform health disparity research through novel “populomics” approaches in a representative population of AsANHPI in the US.

项目摘要 夏威夷是美国最多样化的国家。夏威夷原住民（NH），太平洋岛民（PI）和亚洲人 美国人（ASA）占该州人口的近70％，在美国占NHPI的50％占50％。 该UG3/UH3提案将建立一个新的预期，多代人群来调查 夏威夷NH＆Microseian PI中的心肺和代谢（CPM）健康。这两个截然不同，但是 研究的，亚群体对CPM疾病结局的燃烧过多。糖尿病（DM） 发生在28％的NHPI（> 20y.o。）中，表明> 50％的NHPI具有或处于危险中的DM。 与NONDM相比，NHPI的CVD死亡率高4倍。 CVD死亡率是 NHPI之间的死亡。尽管NHPI进行了数十年的临床和干预研究，但CPM健康不平等 在NH和PI的年轻人中，保持不变，并且正在增加。我们的建议，太平洋 本地观察（PONO）健康遗产研究将直接面对方法论挑战（即 NHPI研究的种族聚集，较小的样本量等，将进行创新的技术驱动 NH＆PI之间改变CPM健康差异进程的“民众学”方法。我们的方法建立 在一个由科学和社区领导人组成的强大跨学科团队中，他们带来了数十年的社区， 临床，流行病学和表观基因组专业知识。我们将与协调中心紧密合作 最大化整体ASA-NHPI队列进行多种假设测试研究的能力。我们的具体 目标（S.A.）如下： S.A.＃1（UG3）：建立一个准，社区参与的，多代人口 夏威夷2500名夏威夷人和太平洋岛民的队列研究。我们的长期合作伙伴关系 伴随着临床和社区的团体，他们对招募，保留和行为标准化充满热情和热情 数据和生物标本收集将投资于子孙后代的健康。 S.A.＃2（UH3）：表征风险和弹性因素与临床血液的关系 与CPM条件相关的代谢和免疫功能的生物标志物。确定的患病率 CPM亚临床疾病与行为协会研究CPM多级风险和弹性因素 状况。 S.A.＃3（UH3）：评估CPM相关风险和弹性因素对事件CPM的影响 随着时间的流逝，夏威夷与NH和PI的连续种群在ASA-之间的结果测量 NHPI队列研究。确定与多层次风险/弹性因素相关的CPM结果的事件和 将数据与总体Asanhpi队列中的相关亚群进行比较。 PONO研究的总体影响是它通过通过 在美国，阿桑皮（Asanhpi）的代表人群中，新颖的“人民学”方法。