Characterization of virulence factors in shigellosis

志贺氏菌病毒力因子的表征

基本信息

  • 批准号:
    10724770
  • 负责人:
  • 金额:
    $ 25.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Abstract The intestinal pathogen Shigella flexneri is the causative agent of bacillary dysentery (bloody diarrhea) and is responsible for more than 250 million cases of dysentery annually, resulting in more than 200,000 deaths. A major challenge in combating bacillary dysentery has been the lack of a small-animal model that recapitulates the symptoms observed in infected individuals. Our group has recently developed a unique model of bacillary dysentery in infant rabbits. In this model, animals infected with S. flexneri experience massive epithelial cell fenestration, vascular lesions, immune cell infiltration, and bloody diarrhea. While the bacterial factors supporting S. flexneri intracellular infection have been chiefly determined using tissue culture systems, we know very little about the virulence determinants leading to pathogenesis in infected individuals. In this application, we propose to use the infant rabbit model in conjunction with Transposon-sequencing approaches to identify and characterize the bacterial factors supporting bacillary dysentery.
摘要 肠道病原体福氏志贺菌是细菌性痢疾(血性腹泻)的病原体, 每年造成2.5亿多起痢疾病例,造成20多万人死亡。一 对抗细菌性痢疾的一个主要挑战是缺乏一个小动物模型, 在感染者身上观察到的症状。我们的团队最近开发了一种独特的细菌模型, 幼兔痢疾在该模型中,感染S.弗氏体经历大量上皮细胞 穿孔、血管病变、免疫细胞浸润和血性腹泻。而细菌因素 支持S.福氏菌胞内感染主要是用组织培养系统确定的, 对导致感染个体发病的毒力决定因素知之甚少。在这 应用,我们建议使用婴儿兔模型结合转座子测序方法 鉴定和表征支持细菌性痢疾的细菌因子。

项目成果

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HERVE F AGAISSE其他文献

HERVE F AGAISSE的其他文献

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{{ truncateString('HERVE F AGAISSE', 18)}}的其他基金

Characterization of an infant rabbit model of bacillary dysentery
幼兔细菌性痢疾模型的表征
  • 批准号:
    10203818
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
High Throughput Screen for Inhibitors of Shigella Flexneri Dissemination
福氏志贺氏菌传播抑制剂的高通量筛选
  • 批准号:
    10626880
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
Characterization of an infant rabbit model of bacillary dysentery
幼兔细菌性痢疾模型的表征
  • 批准号:
    10055925
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
High Throughput Screen for Inhibitors of Shigella Flexneri Dissemination
福氏志贺氏菌传播抑制剂的高通量筛选
  • 批准号:
    10029698
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
Characterization of vacuole escape in Shigella infection
志贺氏菌感染中液泡逃逸的特征
  • 批准号:
    9976031
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
Characterization of vacuole escape in Shigella infection
志贺氏菌感染中液泡逃逸的特征
  • 批准号:
    10088399
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
High Throughput Screen for Inhibitors of Shigella Flexneri Dissemination
福氏志贺氏菌传播抑制剂的高通量筛选
  • 批准号:
    10404510
  • 财政年份:
    2020
  • 资助金额:
    $ 25.38万
  • 项目类别:
Mechanisms of vaccinia virus dissemination
痘苗病毒传播机制
  • 批准号:
    8568531
  • 财政年份:
    2013
  • 资助金额:
    $ 25.38万
  • 项目类别:
Mechanisms of vaccinia virus dissemination
痘苗病毒传播机制
  • 批准号:
    8662699
  • 财政年份:
    2013
  • 资助金额:
    $ 25.38万
  • 项目类别:
Regulation of bacterial pathogen actin-based motility by host cell kinases
宿主细胞激酶对细菌病原体肌动蛋白运动的调节
  • 批准号:
    8095076
  • 财政年份:
    2011
  • 资助金额:
    $ 25.38万
  • 项目类别:

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