Biochemical Parameters Of Bone Metabolism

巴尔的摩老龄化纵向研究的这个项目的目标是描述已经在男性和女性身上证明的与年龄相关的骨量和身体成分的变化。与年龄和性别有关的差异激素、营养和生理变量参与了骨转换，对于阐明正常衰老和疾病时骨生理学的变化是重要的。具体地说，年龄和性别与身体成分变化的关系，既是肥胖的标志，也是骨骼负重负荷的衡量标准，是影响骨骼状态和变化率的重要因素。骨量的变化速度最快的发生在绝经期，正在调查114名年龄在45-55岁之间的女性的身体成分、骨量、骨标记物和激素的变化，这些女性是作为围绝经期队列的一部分被招募到巴尔的摩老龄化纵向研究的。这些女性在进入这项研究时仍在月经，她们在更年期期间每隔3个月进行一次跟踪，自上次月经以来持续两年。这些研究将允许解释月经停止前和停经前后发生的变化，只有在前瞻性的纵向研究中才能理解这些变化。对尚未进入更年期的10-15名妇女的随访于今年终止。对更年期荷尔蒙变化与骨骼和身体成分变化的关系的分析将在明年继续进行。

The goal of this project in the Baltimore Longitudinal Study of Aging is to characterize the age-related changes in bone mass and body composition that have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationships of age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight-bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in 114 women aged 45-55 who have been recruited to the Baltimore Longitudinal Study of Aging as part of the perimenopausal cohort. The women, who were still menstruating, on entry to the study, are followed at 3month intervals as they traverse the menopause, and for two years since their last period. The studies will allow for the interpretation of the changes that occur prior to and mmediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study. The follow-up of the 10-15 women who had not entered their menopause was terminated this year. Analyses examining the relationship of hormonal changes across the menopause period and bone and body composition changes will continue over the next year.