Biochemical Parameters Of Bone Metabolism

巴尔的摩老龄化纵向研究的这个项目的目标是描述与年龄相关的骨量和身体成分的变化，这些变化在男性和女性中都得到了证实。年龄和性别相关的差异激素，营养和生理变量参与骨转换是重要的，在阐明正常衰老和疾病的骨生理变化。具体而言，年龄和性别与身体组成变化的关系，作为肥胖的标志和骨骼承重负荷的衡量标准，是骨骼状态和变化率的重要因素。骨量变化最剧烈的时期是绝经期，114名年龄在45-55岁之间的妇女被纳入巴尔的摩老龄化纵向研究，作为围绝经期队列的一部分，她们的身体成分、骨量、骨标志物和激素的变化正在被研究。这些妇女在进入研究时仍处于绝经期，每隔3个月就接受一次随访，从她们最后一次月经开始，随访时间为两年。这些研究将允许解释月经停止前和停止前后发生的变化，这些变化只能在前瞻性纵向研究中才能理解。对10-15名尚未进入更年期的妇女的随访于今年终止。明年将继续分析更年期荷尔蒙变化与骨骼和身体成分变化的关系。

The goal of this project in the Baltimore Longitudinal Study of Aging is to characterize the age-related changes in bone mass and body composition that have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationships of age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight-bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in 114 women aged 45-55 who have been recruited to the Baltimore Longitudinal Study of Aging as part of the perimenopausal cohort. The women, who were still menstruating, on entry to the study, are followed at 3month intervals as they traverse the menopause, and for two years since their last period. The studies will allow for the interpretation of the changes that occur prior to and mmediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study. The follow-up of the 10-15 women who had not entered their menopause was terminated this year. Analyses examining the relationship of hormonal changes across the menopause period and bone and body composition changes will continue over the next year.