Biochemical Parameters Of Bone Metabolism

巴尔的摩衰老纵向研究项目的目标是描述与年龄相关的骨量和身体成分的变化，这些变化已经在男性和女性中得到证实。与年龄和性别相关的差异激素、营养和生理变量参与骨转换在阐明正常衰老和疾病中骨生理的变化是重要的。具体来说，年龄和性别与身体组成变化的关系，既是肥胖的标志，也是骨骼负重的衡量标准，是骨骼状态和变化率的重要因素。骨量变化最剧烈的时期是绝经期，114名年龄在45-55岁之间的妇女的身体组成、骨量、骨标记物和激素的变化被纳入巴尔的摩老年纵向研究，作为围绝经期队列的一部分。研究人员每隔3个月对仍在经期的女性进行一次随访，并在她们进入更年期后进行两年的随访。这些研究将允许解释在月经停止之前和前后发生的变化，这些变化只能在前瞻性纵向研究中得到赞赏。对未进入更年期的10-15名妇女的随访于今年结束。研究绝经期荷尔蒙变化与骨骼和身体成分变化之间关系的分析将在明年继续进行。

The goal of this project in the Baltimore Longitudinal Study of Aging is to characterize the age-related changes in bone mass and body composition that have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationships of age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight-bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in 114 women aged 45-55 who have been recruited to the Baltimore Longitudinal Study of Aging as part of the perimenopausal cohort. The women, who were still menstruating, on entry to the study, are followed at 3month intervals as they traverse the menopause, and for two years since their last period. The studies will allow for the interpretation of the changes that occur prior to and mmediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study. The follow-up of the 10-15 women who had not entered their menopause was terminated this year. Analyses examining the relationship of hormonal changes across the menopause period and bone and body composition changes will continue over the next year.