Biochemical Parameters Of Bone Metabolism Age

骨代谢生化参数 年龄

• 批准号: 6968766
• 负责人: Earl Jeffrey Metter
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6968766
• 关键词: age difference; aging; biomarker; body composition; bone density; bone metabolism; clinical research; data collection; female; gender difference; human middle age (35-64); human subject; longitudinal human study; menopause; osteoporosis; women' s health

The goal of this project in the Baltimore Longitudinal Study of Aging is to characterize the age-related changes in bone mass and body composition that have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationships of age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight-bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in 114 women aged 45-55 who have been recruited to the Baltimore Longitudinal Study of Aging as part of the perimenopausal cohort. The women, who were still menstruating, on entry to the study, were followed at 3month intervals as they traverse the menopause, and for two years following their last period. The studies examined the changes that occurred prior to and mmediately around the time of the cessation of menses, changes that could only be appreciated in a prospective longitudinal study. Data collection has been completed. Analyses examining the relationship of hormonal changes across the menopause period and bone and body composition changes is contining.

巴尔的摩老龄化纵向研究的这个项目的目标是描述已经在男性和女性身上证明的与年龄相关的骨量和身体成分的变化。与年龄和性别有关的差异激素、营养和生理变量参与了骨转换，对于阐明正常衰老和疾病时骨生理学的变化是重要的。具体地说，年龄和性别与身体成分变化的关系，既是肥胖的标志，也是骨骼负重负荷的衡量标准，是影响骨骼状态和变化率的重要因素。骨量的变化速度最快的发生在绝经期，正在调查114名年龄在45-55岁之间的女性的身体成分、骨量、骨标记物和激素的变化，这些女性是作为围绝经期队列的一部分被招募到巴尔的摩老龄化纵向研究的。这些女性在进入研究时仍在月经，在她们进入更年期期间每隔3个月进行一次跟踪，并在她们最后一次月经后的两年内进行跟踪。这些研究考察了月经停止前后发生的变化，这些变化只有在前瞻性的纵向研究中才能得到评价。数据收集工作已经完成。对更年期荷尔蒙变化与骨骼和身体成分变化的关系的分析仍在继续。