African American Attitudes Toward HPV Vaccination

非裔美国人对 HPV 疫苗接种的态度

• 批准号: 7459246
• 负责人: GRAHAM A. COLDITZ
• 金额: $ 7.46万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7459246
• 关键词: Accounting; Address; Affect; African American; Age-Years; Attitude; Awareness; Cancer Center; Child; Cities; Clinical Research; Collaborations; Communities; Community Networks; Community Participation; County; Cross-Sectional Studies; Cultural Characteristics; Data; Depth; Education; Effectiveness; Environmental Risk Factor; Female; Funding; Future; Gardasil; General Population; Genital system; Growth; Human; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunization; Incidence; Income; Individual; Insurance Coverage; Intervention; Interview; Knowledge; Leadership; Location; Low income; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of penis; Measures; Metric; Minor; Missouri; Monitor; Other Minority; Papillomavirus; Parents; Persons; Pregnancy in Adolescence; Prevalence; Prevention; Provider; Purpose; Rate; Research; Research Infrastructure; Research Personnel; Screening procedure; Secondary Prevention; Sex Behavior; Sexually Transmitted Diseases; Skin Carcinoma; Students; Surveys; Testing; Training Programs; Vaccinated; Vaccination; Vaccines; Virus; Woman; Work; base; cancer education; cancer health disparity; girls; high school; interest; member; men; mortality; multidisciplinary; parental influence; programs; prophylactic; research study; social; therapy design

DESCRIPTION (provided by applicant): African American cervical cancer mortality rates for Missouri are higher than those observed in the general population; and mortality rates in St. Louis City and county exceed the African American mortality rates for the state. Human Papillomavirus (HPV) is one of the most common sexually transmitted infections among young people and it is associated with cervical cancer in women. The higher cervical cancer incidence and mortality rates observed among African Americans in St. Louis suggests the importance of HPV screening and vaccination for this community. While HPV consists of over 30 types of viruses that can be passed from one person to another through sexual contact, the HPV 16 virus accounts for approximately half of all cervical cancers in the world. Its prevalence in the US is highest among African American women (19.1 percent) compared to 12.5 percent among white women. There is now an approved prophylactic vaccine, Gardasil, available. The vaccine is recommended for girls 11 to12 years of age, but can be given to girls as young as nine and is also recommended for girls 13-18 year to catch up on or complete missed shots. Giving the vaccine to young girls is important because the vaccine is most effective when given to people prior to HPV infection. Surveys show that 68% of African American high school students are sexually active, which can result in HPV infection. St. Louis city is over 50% African American, with notable disparities in the teen pregnancy and sexually transmitted disease rates. These facts support the need for early vaccination if young African American girls are to be adequately protected from the effect of HPV. Historically, where there are no penalties or mandated vaccination requirements, immunization levels are consistently lower in the African American community compared to those of Whites or other minorities; a fact that suggests the need to assure that parents in the African American community are well-educated on HPV, HPV vaccination, and that we address barriers to vaccination. Working with our community partners, this project seeks to assess HPV knowledge, awareness of the vaccine, its benefits, and barriers to vaccination. We will conduct a cross sectional survey of 200 African American parents, and complete in depth interviews with 30 randomly selected parents to address three specific aims. The specific aims of this research effort are to: 1) determine knowledge about HPV, HPV vaccination and its relationship to cancer among African American parents; 2) determine acceptability of and intent to vaccinate among parents of African American girls nine to 17; and 3) describe the individual characteristics, cultural attitudes, social and environmental factors that affect African American parents' intent to vaccinate girls, nine to 17, against HPV. These data will be used to develop and test a culturally sensitive intervention designed to reduce the likelihood that disparities in HPV vaccination will emerge in the St. Louis African American community. The Siteman Cancer Center (SCC) Program for the Elimination of Cancer Disparities (PECaD) is a multi- disciplinary community-focused program established to eliminate pervasive disparities of cancer education, prevention, and treatment. The SCC Senior Leadership made this program a top priority, and it subsequently developed a substantial infrastructure and scientific portfolio, which will be further strengthened by this proposal. Specific aims for the first year are: 1) To further develop the core organizational infrastructure within the SCC to support community-based participatory activities to reduce cancer health disparities by establishing a staff of multidisciplinary professionals critical to implementing the program. 2) To enhance existing relationships and build new partnerships with communities that suffer cancer health disparities and with other organizations with an interest in reducing cancer health disparities among members of these communities. 3) To form or further develop at least four collaborations with other NCI programs (i.e., NCI Centers/Divisions/offices other than the NCI Center to Reduce Cancer Health Disparities) for the purpose of reducing cancer health disparities. 4) To increase utilization of beneficial interventions to reduce cancer health disparities. 5) To leverage Community Networks Program (CNP) activities by maintaining and obtaining new non- CRCHD funding for community-based participatory activities directed at reducing cancer health disparities. 6) To identify specific metrics to measure effectiveness of this project. 7) To increase community participation in primary and secondary prevention activities. 8) To identify specific barriers to proportional accrual in clinical research studies. 9) To plan training program activities for investigators, staff, and trainees with regard to overcoming disparities and disparities-focused research. Aims in years 2-5 will focus on developing, monitoring, and measuring effectiveness of these activities, and on building and leveraging funding to sustain program growth in the future.

描述（由申请人提供）：密苏里州的非裔美国人宫颈癌死亡率高于一般人群;圣路易斯市和县的死亡率超过该州的非裔美国人死亡率。人乳头瘤病毒（HPV）是年轻人中最常见的性传播感染之一，与女性宫颈癌有关。在圣路易斯的非裔美国人中观察到的较高的宫颈癌发病率和死亡率表明HPV筛查和疫苗接种对该社区的重要性。虽然HPV由30多种病毒组成，可以通过性接触从一个人传播到另一个人，但HPV 16病毒占世界上所有宫颈癌的大约一半。在美国，非裔美国妇女的患病率最高（19.1%），而白色妇女的患病率为12.5%。现在有一种经批准的预防性疫苗Gardasil可用。该疫苗推荐给11至12岁的女孩，但也可以给9岁的女孩，也推荐给13至18岁的女孩，以赶上或完成错过的注射。给年轻女孩接种疫苗很重要，因为疫苗在HPV感染前给人接种时最有效。调查显示，68%的非洲裔美国高中生性活跃，这可能导致HPV感染。圣路易斯市有超过50%的非裔美国人，在青少年怀孕和性传播疾病的发病率方面存在显着差异。这些事实支持早期接种疫苗的必要性，如果年轻的非洲裔美国女孩要充分保护免受HPV的影响。从历史上看，在没有惩罚或强制性疫苗接种要求的情况下，与白人或其他少数民族相比，非洲裔美国人社区的免疫水平一直较低;这一事实表明，需要确保非洲裔美国人社区的父母在HPV，HPV疫苗接种方面受到良好教育，并且我们解决了接种疫苗的障碍。与我们的社区合作伙伴合作，该项目旨在评估HPV知识，疫苗意识，其好处和接种疫苗的障碍。我们将对200名非裔美国父母进行横断面调查，并与30名随机选择的父母进行深入访谈，以解决三个具体目标。这项研究工作的具体目标是：1）确定非洲裔美国人父母对HPV、HPV疫苗接种及其与癌症关系的认识; 2）确定9至17岁非洲裔美国女孩父母接种疫苗的可接受性和意向;描述影响非裔美国父母给女孩接种疫苗意图的个人特征、文化态度、社会和环境因素，9到17岁，对抗HPV。这些数据将用于开发和测试一种文化敏感的干预措施，旨在减少圣路易斯非裔美国人社区出现HPV疫苗接种差异的可能性。 Siteman癌症中心（SCC）消除癌症差异计划（PECaD）是一项以社区为重点的多学科计划，旨在消除癌症教育、预防和治疗的普遍差异。SCC高级领导层将该计划列为重中之重，随后开发了大量的基础设施和科学组合，这将通过该提案进一步加强。第一年的具体目标是：1）进一步发展SCC内部的核心组织基础设施，以支持以社区为基础的参与性活动，通过建立对实施该计划至关重要的多学科专业人员来减少癌症健康差距。2)加强现有的关系，并建立新的伙伴关系，与社区遭受癌症健康的差距，并与其他组织有兴趣在减少这些社区的成员之间的癌症健康差距。3)形成或进一步发展与其他NCI计划的至少四个合作（即，NCI减少癌症健康差异中心以外的NCI中心/部门/办公室），以减少癌症健康差异。4)增加有益干预措施的利用，以减少癌症健康差距。5)通过维持和获得新的非CRCHD资金，利用社区网络计划（CNP）活动，以减少癌症健康差异。6)确定衡量项目有效性的具体指标。7)加强社区对初级和二级预防活动的参与。8)确定临床研究中按比例增加的具体障碍。9)为研究者、工作人员和受训人员规划培训计划活动，以克服差异和以能力为重点的研究。第2-5年的目标将侧重于开发、监测和衡量这些活动的有效性，以及建立和利用资金来维持未来的计划增长。