Multi-modal spatial genomics in the mouse and human brains

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SUMMARY The major goal of this project is to build upon our existing expertise and platform to develop spatial multi-omics tools in human brains. At Spatial Genomics, we are commercializing the sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to be imaged directly in brain samples. We have developed extensive experience working with mouse and human brains with our seqFISH technology. Spatial genomics methods have the potential to identify novel cell types, reveal spatial organization of groups of cells and subcellular patterns, and elucidate signaling interactions between neighboring cells in the brain. Identifying the spatial organization of the human brain at cellular resolution from single cell gene expression profiles is essential to understanding neuronal circuits and interactions between neurons and glia.