Statistical Analysis of Hippocampal Information Encoding

海马信息编码的统计分析

基本信息

  • 批准号:
    7404549
  • 负责人:
  • 金额:
    $ 41.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-02-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Neurons in the rat hippocampal formation play an important role in spatial information encoding. The neurons in the different regions of this medial temporal lobe structure have different spatial and temporal firing properties, suggesting differences in the way information is processed through the regions. The specific aims of this project are to: 1) develop accurate statistical models of single neurons in CA3, the subiculum, and the entorhinal cortex that describe the relationship between neural spiking activity and relevant covariates such as the position of the animal in its environment, theta phase, theta phase precession, bursting, running velocity and the spiking history of other neurons; 2) develop accurate statistical models that describe the joint spiking activity of sets of neurons in order to measure coordinated spiking activity patterns across an ensemble of simultaneously recorded neurons within the same region or a different region; 3) test the hypothesis that the effects of behavioral correlates on single neuron activity in CA3, CA1, subiculum and the deep entorhinal cortex differ according to whether the animal is performing a task that either does or does not depend on an intact hippocampus; and 4) test the hypothesis that patterns of coordinated multiple neuron activity in CA3, CA1, the subiculum and the deep entorhinal cortex differ according to whether the animal is performing a task that either does or does not depend on an intact hippocampus. These differences in coordinated activity may offer insight into how the rat hippocampus maintains representations of relevant spatial information and facilitates transfer of that information to other brain regions. The experimental methods will include use of multielectrode arrays to record simultaneously the activity of neurons in the hippocampal formation, as well as application of point process theory to develop accurate statistical methods to characterize the firing properties of hippocampal ensembles and their relation to behavioral and neurophysiological covariates. The broad long-term objectives are to: develop a statistical paradigm tailormade for the analysis of spike trains from multiple electrode recordings; and characterize how ensemble neuronal activity in the hippocampal formation represents information in short-term memory and how it aids in encoding and retrieval of information from long-term memory. The potential health benefits of the experimental research are a better understanding of the basic neurophysiology of hippocampal dependent memory processes and insight into how to develop new treatments for memory dysfunction. More accurate characterizations of neuronal dynamics may also lead to more physiologically-sound approaches to creating machine-brain interfaces and designing neural prosthetic devices.
描述(申请人提供):大鼠海马区神经元在空间信息编码中起重要作用。内侧颞叶结构不同区域的神经元具有不同的空间和时间放电特性,这表明信息通过这些区域处理的方式存在差异。本项目的具体目标是:1)建立CA3、枕下和内嗅皮层单个神经元的精确统计模型,描述神经尖峰活动与相关协变量(如动物在环境中的位置、θ相、θ相进动、爆发、运行速度和其他神经元的尖峰历史)之间的关系;2)建立准确的统计模型,描述神经元集合的联合尖峰活动,以测量同一区域或不同区域内同时记录的神经元集合的协调尖峰活动模式;3)验证行为相关因素对CA3、CA1、下带和深内嗅皮层单个神经元活动的影响,这一假设取决于动物是否在执行任务时依赖于完整的海马体;4)验证CA3、CA1、枕下和深内嗅皮层中协调的多神经元活动模式根据动物是否执行任务依赖于完整的海马体而有所不同的假设。这些协调活动的差异可能会让我们深入了解大鼠海马体如何维持相关空间信息的表征,并促进信息向其他大脑区域的转移。实验方法将包括使用多电极阵列同时记录海马形成中的神经元活动,以及应用点过程理论开发准确的统计方法来表征海马集合的放电特性及其与行为和神经生理协变量的关系。广泛的长期目标是:开发一种统计范式,用于分析多个电极记录的尖峰序列;并描述海马体结构中的集合神经元活动如何代表短期记忆中的信息,以及它如何帮助从长期记忆中编码和检索信息。实验研究的潜在健康益处是更好地理解海马依赖性记忆过程的基本神经生理学,并深入了解如何开发新的治疗记忆功能障碍的方法。更准确的神经元动力学特征也可能导致更多的生理健全的方法来创建机器-脑接口和设计神经假体装置。

项目成果

期刊论文数量(33)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rapid changes in thalamic firing synchrony during repetitive whisker stimulation.
Automatic filters for the detection of coherent structure in spatiotemporal systems.
用于检测时空系统中相干结构的自动滤波器。
Discrete time rescaling theorem: determining goodness of fit for discrete time statistical models of neural spiking.
  • DOI:
    10.1162/neco_a_00015
  • 发表时间:
    2010-10
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Haslinger R;Pipa G;Brown E
  • 通讯作者:
    Brown E
Instantaneous frequency and amplitude modulation of EEG in the hippocampus reveals state dependent temporal structure.
海马体脑电图的瞬时频率和幅度调制揭示了状态依赖的时间结构。
Measuring instantaneous frequency of local field potential oscillations using the Kalman smoother.
测量使用卡尔曼更光滑的局部场电位振荡的瞬时频率。
  • DOI:
    10.1016/j.jneumeth.2009.08.012
  • 发表时间:
    2009-11-15
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Nguyen DP;Wilson MA;Brown EN;Barbieri R
  • 通讯作者:
    Barbieri R
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EMERY N BROWN其他文献

EMERY N BROWN的其他文献

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{{ truncateString('EMERY N BROWN', 18)}}的其他基金

Investigating the neurophysiological basis of circuit-specific laminar rs-fMRI
研究电路特异性层流 rs-fMRI 的神经生理学基础
  • 批准号:
    10518479
  • 财政年份:
    2022
  • 资助金额:
    $ 41.94万
  • 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
  • 批准号:
    10610946
  • 财政年份:
    2022
  • 资助金额:
    $ 41.94万
  • 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
  • 批准号:
    10445654
  • 财政年份:
    2022
  • 资助金额:
    $ 41.94万
  • 项目类别:
Core B: Administrative Core
核心 B:行政核心
  • 批准号:
    9209575
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
Project 1: Human Studies of Anesthetic Action
项目 1:麻醉作用的人体研究
  • 批准号:
    10093071
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
  • 批准号:
    10093061
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
  • 批准号:
    9209574
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
全身麻醉下老化的大脑:神经生理学、衰老和阿尔茨海默病的神经影像生物标志物以及术后认知结果
  • 批准号:
    9904463
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
Thalamocortical Dynamics and Consciousness
丘脑皮质动力学和意识
  • 批准号:
    10199752
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:
Core A: Data Analysis Core
核心A:数据分析核心
  • 批准号:
    10093068
  • 财政年份:
    2017
  • 资助金额:
    $ 41.94万
  • 项目类别:

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