The Neurocognitive Profile: A High Efficiency Integrated Brain-Behavior Assay

神经认知概况：高效的大脑行为综合分析

基本信息

批准号：
7488981
负责人：
Chris Berka
金额：
$ 20万
依托单位：
ADVANCED BRAIN MONITORING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-24 至 2009-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7488981
关键词：
Area Attention Behavioral Biological Assay Collaborations Continuous Positive Airway Pressure Daily Data Development Diagnosis Drug Addiction Electroencephalogram Electroencephalography Equipment and supply inventories Evaluation Evolution Forensic Medicine Foundations Impaired cognition Individual Investigation Laboratories Learning Measures Medicine Memory Memory impairment Mental disorders Methods Military Personnel Neurocognitive Neurologic Neuropsychological Tests New York Obstructive Sleep Apnea Occupational Medicine Patient Self-Report Patients Pharmacologic Substance Phase Play Protocols documentation Quality of life Range Rehabilitation therapy Research Personnel Role Sleep Sleep Deprivation Sports Medicine System Technical Expertise Testing Time Training and Education Treatment Efficacy Universities Visuospatial Work alertness behavior test biobehavior brain behavior clinical application design ergonomics interest neurophysiology neuropsychological performance tests processing speed prototype vigilance

项目摘要

DESCRIPTION (provided by applicant): Alterations in neurocognitive function play a major role in numerous sleeps, neurological and psychiatric disorders and can have a significant impact on quality of life, treatment efficacy, rehabilitation and ability to function at work and in normal daily activities. The methods currently available for neurocognitive investigations including traditional neuropsychological assessment (e.g. Halstead-Reitan, Wechsler memory battery), neurophysiological measures (e.g. electroencephalogram, Multiple Sleep Latency Test) and behavioral tests (e.g. Continuous Performance Test, Psychomotor Vigilance Test) are time-consuming, expensive and often require substantial technical expertise to administer and interpret. The Alertness and Memory Profiling (AMP) system integrates neurophysiological, behavioral and subjective measures in a platform designed for quantitative assessment of neurocognitive functions including alertness, attention, learning and memory. The AMP employs a multivariate approach, combining EEG, neuropsychological tests and validated self-report inventories in an easy-to-administer set of protocols. Initial investigations revealed that AMP could be used to characterize the changes in alertness, learning and memory associated with sleep deprivation in healthy subjects and to provide a biobehavioral assay that identified those Individuals most and least susceptible to the effects of sleep deprivation. The AMP also proved sensitive and specific in discriminating patients with the highly prevalent, under-diagnosed Obstructive Sleep Apnea (OSA) from healthy subjects. The AMP characterized individual profiles of alertness and memory impairment and quantified the amelioration of some cognitive impairments following treatment with CPAP. Four neurocognitive factors were derived from the AMP data: sustained attention, processing speed, verbal memory and visuospatial memory. Preliminary investigations with the AMP prototype systems have resulted in inquiries from a wide range of researchers and clinicians interested in applying the AMP to investigations in sleep medicine, drug addiction, pharmaceutical evaluation, forensic investigations, ergonomics, sports medicine, military applications, education/training evaluations, and occupational medicine. The plan for the Phase I is to build upon this foundation of work in the area of sleep medicine, and extend the development of AMP platform to accommodate the range of potential applications and to take the next step in the evolution of the AMP product in a clinical applications study in collaboration with the New York University sleep laboratory.

描述（由申请人提供）：神经认知功能的改变在众多睡眠，神经和精神疾病中起着重要作用，并且可能对生活质量，治疗效果，康复以及在工作和正常日常活动中功能的能力产生重大影响。目前可用于神经认知研究的方法，包括传统的神经心理学评估（例如Halstead-Reitan，Wechsler记忆电池），神经生理学测量（例如，脑电图，多睡眠潜伏期测试）和行为测试（例如，持续的绩效测试，心理警惕性测试）是既有时间的，又需要计时的，并经常进行计时。机敏性和记忆分析（AMP）系统将神经生理，行为和主观度量集成到一个平台中，旨在定量评估神经认知功能，包括警觉性，注意力，学习和记忆。 AMP采用了一种多元方法，将脑电图，神经心理学测试和验证的自我报告清单结合在一起，以易于管理的协议集。初步调查表明，AMP可以用来表征健康受试者中与睡眠剥夺相关的警觉性，学习和记忆的变化，并提供生物行为测定法，以确定这些测定个体最容易受到睡眠剥夺的影响。在健康受试者中，AMP还证明了对具有高度普遍，未经诊断的阻塞性睡眠呼吸暂停（OSA）的患者的敏感和特异性。 AMP表征了机敏性和记忆力障碍的个体特征，并量化了用CPAP治疗后一些认知障碍的改善。四个神经认知因素来自AMP数据：持续的注意力，处理速度，言语记忆和视觉空间记忆。对AMP原型系统进行的初步研究导致了有兴趣将AMP应用于睡眠医学，药物成瘾，药物评估，法医研究，运动医学，运动医学，军事应用，教育/培训评估和职业医学研究的广泛研究人员和临床医生的询问。第一阶段的计划是建立在睡眠医学领域的工作基础，并扩展AMP平台的开发，以适应潜在应用的范围，并在与纽约大学睡眠实验室合作的临床应用研究中迈出AMP产品的下一步。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Behavioral and Neurophysiological Signatures of Benzodiazepine-Related Driving Impairments.

DOI：
10.3389/fpsyg.2015.01799
发表时间：
2015
期刊：
Frontiers in psychology
影响因子：
3.8
作者：
Stone BT;Correa KA;Brown TL;Spurgin AL;Stikic M;Johnson RR;Berka C
通讯作者：
Berka C

Characterizing donation behavior from psychophysiological indices of narrative experience.

DOI：
10.3389/fnins.2015.00301
发表时间：
2015
期刊：
Frontiers in neuroscience
影响因子：
4.3
作者：
Correa KA;Stone BT;Stikic M;Johnson RR;Berka C
通讯作者：
Berka C

Correlation of EEG biomarkers of cannabis with measured driving impairment.

DOI：
10.1080/15389588.2019.1662256
发表时间：
2019
期刊：
Traffic injury prevention
影响因子：
2
作者：
Brown T;McConnell M;Rupp G;Meghdadi A;Richard C;Schmitt R;Gaffney G;Milavetz G;Berka C
通讯作者：
Berka C

Elevated Inter-Brain Coherence Between Subjects With Concordant Stances During Discussion of Social Issues.