Targeted in vivo Micro Platform for Nanodevices

用于纳米器件的靶向体内微平台

• 批准号: 7932980
• 负责人: ROGER Y TSIEN
• 金额: $ 52.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7932980
• 关键词: Animal Model; Binding; Biomimetics; Blood Circulation; Blood Vessels; Cancerous; Cell Survival; Cell membrane; Cells; Characteristics; Chemistry; Detection; Devices; Engineering; Erythrocytes; Heating; Homing; Image; In Vitro; Magnetism; Measurement; Methods; Modification; Morphology; Mothers; Nanostructures; Nanotechnology; Nanotubes; Optics; Oxides; Particle Size; Peptides; Pharmaceutical Preparations; Preparation; Property; Reporting; Research Personnel; Reticuloendothelial System; Rupture; Sailor; Shapes; Shipping; Ships; Silicon; Structure; Surface; System; Testing; Toxic effect; Ultrasonics; antitumor drug; aqueous; base; biomaterial compatibility; design; experience; in vivo; nano; nanodevice; nanoparticle; nanosized; nanostructured; oxidation; oxidative damage; particle; prototype; radiofrequency; response; scaffold; seal; tumor; tumor specificity

A group of investigators with complementary expertise has been assembled to construct micron-sized devices ("mother ships") that are equipped with nano-sized features and that are capable of homing into cancerous tumors in vivo and performing various tasks in the tumor. These tasks include detecting, identifying, and imaging a tumor, performing measurements on it, and delivering therapies. The system will be based on micron-sized, nanostructured porous particles composed primarily of silicon or silicon oxides. The mother ship design concept and silicon-based scaffolding were chosen for a number of reasons: (1) The micron-range size makes it possible to use silicon while retaining its unique engineering features such as optical and radiofrequency reporting properties, high-capacity nano-porous carrier structure, biocompatibility and bioresorbability; (2) This applicant group has extensive experience with nanostructured silicon microdevices, and prototype mother ship particles resembling red blood cells have already been constructed and tested in-vivo; (3) Preliminary results suggest that micron-sized particles coated with tumor-specific vascular homing peptides become lodged in tumor vasculature; (4) Micronsized particles, unlike nanoparticles, are not taken up by the reticuloendothelial system; (5) The mother ship can be extensively functionalized with nanoparticles, nanotubes, drugs, and imaging agents in a controlled fashion.

一组具有互补专业知识的研究人员已经聚集在一起， 设备（“母舰”），配备了纳米尺寸的功能，并能够归巢到 在体内的癌性肿瘤和在肿瘤中执行各种任务。这些任务包括检测， 对肿瘤进行识别和成像，对其进行测量，并提供治疗。系统 将基于主要由硅或硅纳米结构组成的微米尺寸的多孔颗粒 氧化物母船设计概念和硅基脚手架被选择用于一些 原因：（1）微米级的尺寸使其可以使用硅，同时保留其独特的工程 具有光学和射频报告特性、高容量纳米多孔载体 结构、生物相容性和生物可吸收性;（2）该申请人小组在以下方面具有丰富的经验： 纳米结构的硅微器件和类似于红细胞的原型母舰颗粒， 已经构建并在体内测试;（3）初步结果表明，微米级颗粒 包被有肿瘤特异性血管归巢肽的细胞在肿瘤血管系统中沉积;（4）大小不一的 与纳米颗粒不同，颗粒不被网状内皮系统吸收;（5）母体 船舶可以广泛功能化纳米粒子，纳米管，药物和成像剂， 控制时尚