COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

COBRE 儿童和青少年心理健康睡眠和昼夜节律中心

• 批准号: 10090146
• 负责人: Mary A Carskadon
• 金额: $ 203.14万
• 依托单位: EMMA PENDLETON BRADLEY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-06 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090146
• 关键词: 17q12; Adolescence; Adolescent; Adolescent Psychiatry; Affect; Attention deficit hyperactivity disorder; Behavioral; Career Mobility; Centers of Research Excellence; Characteristics; Child; Child Mental Health; Child Psychiatry; Child Welfare; Childhood; Chronobiology; Circadian Rhythms; Clinical; Cognitive; Collection; Complex; Computer software; Consultations; Copy Number Polymorphism; Core Facility; Country; DNA copy number; DSM-V; Data; Databases; Development; Diagnostic; Doctor of Philosophy; Drowsiness; Early Intervention; Epidemiologist; Evaluation; Faculty; Family; Feeling suicidal; Functional Magnetic Resonance Imaging; Funding; Genes; Goals; Green space; Growth; Health; Heart; Home; Hospitals; Impaired cognition; Incidence; Infrastructure; Institutes; Institution; Laboratories; Leadership; Link; Longevity; Maintenance; Measures; Memory; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Nature; Occupational activity of managing finances; Participant; Pathway interactions; Phenotype; Pilot Projects; Psychiatrist; Psychologist; Research; Research Methodology; Research Personnel; Resources; Rhode Island; Schizophrenia; Schools; Science; Scientist; Seeds; Sleep; Sleep disturbances; Structure; Technology; Training; United States National Institutes of Health; Vulnerable Populations; Work; Youth; autism spectrum disorder; base; career; circadian; circadian pacemaker; clinical care; design; faculty mentor; health assessment; improved; instrumentation; knowledge base; multidisciplinary; neuropsychiatric disorder; neuropsychiatry; neuropsychopharmacology; preventive intervention; programs; psychobiology; recruit; sleep behavior; sleep health; sleep pattern; social; suicidal risk; theories; therapeutic target

PROJECT SUMMARY ABSTRACT This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to prevention and early intervention, not the least because these factors are amenable to behavioral change and to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge base and relevant research methods to the outstanding mental health research and clinical care that characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train, mentor, and support junior investigators toward independent research careers. The Center’s research Cores will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research approaches and methods, and research participants. Four promising young investigators have each proposed a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep, circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene. Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health. Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill its place as a true center of biomedical research excellence is strong, and the most important, special, and notable aspect of this proposed center is the vulnerable population that forms the heart of our work.

项目摘要 这个COBRE将建立一个儿童和青少年心理睡眠和昼夜节律中心， 健康在EP布拉德利医院在罗得岛。布拉德利医院是美国独一无二的精神病医院。 专门关注儿童问题机构和儿童和青少年研究的国家资源 精神病学精神疾病和睡眠之间的联系是无可争议的;探索和确定从睡眠中的联系， 睡眠和昼夜节律对儿童精神疾病和精神健康的影响可以确定重要的途径， 预防和早期干预，尤其是因为这些因素可以改变行为， 明确的治疗靶点这个COBRE的目的是建立一个桥梁，从睡眠和昼夜节律的知识， 基础和相关的研究方法，以优秀的心理健康研究和临床护理， 描述布拉德利医院。拟议中的COBRE中心将是第一个也是唯一一个由NIH资助的研究 中心有一个明确的重点是睡眠，昼夜节律，和儿科心理健康。该中心将培训， 指导并支持初级研究人员走向独立研究职业。中心的研究核心 将举办儿科心理健康评估、睡眠和昼夜节律理论、科学和 方法.该COBRE中心的目标是建立和建设一个全面和可持续的 资源，以支持儿童睡眠，昼夜节律和心理健康研究的增长， 为初级项目负责人提供研究和向独立科学过渡的指导 有外部资金的职业。该中心致力于教师，导师，调查人员，研究人员的多样性。 方法和方法，以及研究参与者。四个有前途的年轻调查员 这个项目突出了这一奋进的多样性和复杂性。项目1将测量睡眠， 昼夜节律定时和功能磁共振成像评估自我批评反刍和自我保证的青少年在风险， 自杀的想法和行为。项目2评估睡眠模式和昼夜节律的时间在年轻人谁有一个 一种罕见的与自闭症和精神分裂症相关的DNA拷贝数变异，包括生物钟基因。 项目3评估学校儿童（1-3年级）使用绿色空间如何影响睡眠和心理健康。 项目4使用了一种强化睡眠和时间生物学的实验室方法来确定睡眠和记忆是如何 注意缺陷多动障碍（ADHD）的早期青少年受睡眠生物调节的影响， 因素COBRE的最终目标是减轻儿童、青少年和 通过提高研究人员的队伍和能力来帮助他们的家庭。眼镜蛇的承诺是 它作为一个真正的生物医学研究卓越中心的地位是强大的，最重要的，特殊的， 这个拟议的中心值得注意的一点是，弱势群体是我们工作的核心。