COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

项目总结摘要 该中心将建立一个儿童和青少年心理睡眠和昼夜节律研究中心 罗德岛EP Bradley医院的健康状况。布拉德利医院在美国是独一无二的精神病院 专门致力于儿童的机构，是儿童和青少年研究的国家资源 精神病学。精神疾病和睡眠之间的联系是毋庸置疑的；从 睡眠和昼夜节律对儿童精神疾病和精神健康的影响可以确定 预防和早期干预，尤其是因为这些因素容易受到行为变化和 明确的治疗目标。Cobre的目标是在睡眠和昼夜节律知识之间架起一座桥梁 对优秀的心理健康研究和临床护理的基础和相关研究方法 布拉德利医院的特点。拟议中的科布雷中心将是美国国立卫生研究院资助的第一项也是唯一一项研究 中心明确关注睡眠、昼夜节律和儿科精神健康。该中心将进行培训， 指导和支持初级调查人员走向独立的研究生涯。该中心的研究核心 将主持儿童心理健康评估以及睡眠和昼夜节律理论、科学和 方法：研究方法。科布雷中心的目标是建立和建设一个全面的、可持续的 支持儿科睡眠、昼夜节律和心理健康方面的研究增长的资源，同时 为初级项目负责人提供研究和过渡到独立科学研究的指导 有外部资助的职业生涯。该中心致力于教师、导师、研究人员、研究人员的多样性 途径和方法，以及研究参与者。四名有前途的年轻调查人员各自提出了 这一项目突出了这一努力的多样性和复杂性。项目1将测量睡眠， 昼夜节律计时和功能磁共振成像评估患癌症风险青少年的自我反省和自我保证 自杀的念头和行为。项目2评估患有睡眠障碍的青少年的睡眠模式和昼夜节律 罕见的DNA拷贝数变异与自闭症和精神分裂症有关，并包括一个生物钟基因。 项目3评估在校儿童(1-3年级)使用绿地对睡眠和心理健康的影响。 项目4在实验室中使用密集睡眠和时间生物学的方法来确定嗜睡和记忆 注意缺陷多动障碍(ADHD)青少年早期受睡眠生物调节的影响 各种因素。Cobre的最终目标是减轻儿童、青少年和 通过加强研究队伍和能力，为他们的家人提供帮助。这个科布雷要兑现的诺言 它作为一个真正的生物医学研究卓越中心的地位是强大的，最重要的，特别的，和 这个拟建的中心值得注意的是，弱势群体构成了我们工作的核心。

PROJECT SUMMARY ABSTRACT This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to prevention and early intervention, not the least because these factors are amenable to behavioral change and to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge base and relevant research methods to the outstanding mental health research and clinical care that characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train, mentor, and support junior investigators toward independent research careers. The Center’s research Cores will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research approaches and methods, and research participants. Four promising young investigators have each proposed a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep, circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene. Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health. Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill its place as a true center of biomedical research excellence is strong, and the most important, special, and notable aspect of this proposed center is the vulnerable population that forms the heart of our work.