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COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

COBRE 儿童和青少年心理健康睡眠和昼夜节律中心

基本信息

批准号：
10385694
负责人：
Mary A Carskadon
金额：
$ 200.97万
依托单位：
EMMA PENDLETON BRADLEY HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-06 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10385694
关键词：
17q12 Adolescence Adolescent Adolescent Psychiatry Affect Attention deficit hyperactivity disorder Behavioral Career Mobility Centers of Research Excellence Characteristics Child Child Mental Health Child Psychiatry Child Welfare Childhood Chronobiology Circadian Rhythms Clinical Cognitive Collection Complex Computer software Consultations Copy Number Polymorphism Core Facility Country DNA copy number DSM-V Data Databases Development Diagnostic Doctor of Philosophy Drowsiness Early Intervention Epidemiologist Evaluation Faculty Family Feeling suicidal Functional Magnetic Resonance Imaging Funding Genes Goals Green space Growth Health Heart Home Hospitals Impaired cognition Incidence Infrastructure Institutes Institution Laboratories Leadership Link Longevity Maintenance Measures Memory Mental Health Mental disorders Mentors Mentorship Methods Nature Occupational activity of managing finances Participant Pathway interactions Phenotype Pilot Projects Psychiatrist Psychologist Research Research Methodology Research Personnel Resources Rhode Island Schizophrenia Schools Science Scientist Seeds Sleep Sleep disturbances Structure Technology Training United States National Institutes of Health Vulnerable Populations Work Youth autism spectrum disorder base career circadian circadian pacemaker clinical care design faculty mentor health assessment improved instrumentation knowledge base multidisciplinary neuropsychiatric disorder neuropsychiatry neuropsychopharmacology preventive intervention programs psychobiology recruit rumination sleep behavior sleep health sleep pattern social suicidal risk sustainable resource theories therapeutic target

项目摘要

PROJECT SUMMARY ABSTRACT This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to prevention and early intervention, not the least because these factors are amenable to behavioral change and to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge base and relevant research methods to the outstanding mental health research and clinical care that characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train, mentor, and support junior investigators toward independent research careers. The Center’s research Cores will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research approaches and methods, and research participants. Four promising young investigators have each proposed a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep, circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene. Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health. Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill its place as a true center of biomedical research excellence is strong, and the most important, special, and notable aspect of this proposed center is the vulnerable population that forms the heart of our work.

项目摘要