Supplement: Design and Model-Based Safety Verification of a Volitional Sit-Stand Controller for a Powered Knee-Ankle Prosthesis

补充：动力膝踝假肢自主坐站控制器的设计和基于模型的安全验证

• 批准号: 10785336
• 负责人: Daphna Raquel Raz
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10785336
• 关键词: Address; Adopted; Adoption; Agreement; Algorithms; American; Amputation; Amputees; Area; Artificial Leg; Back Pain; Behavior; Benchmarking; Biological; Certification; Characteristics; Child Care; Communication; Communities; Computer Systems; Computer software; Data Set; Development; Device Safety; Device or Instrument Development; Devices; Dimensions; Ensure; Environment; Equipment; Exhibits; Failure; Feedback; Force of Gravity; Formulation; Gait; Goals; High Performance Computing; Hip region structure; Human; Individual; Infrastructure; Infusion Pumps; Joints; Knee; Leg; Link; Literature; Lower Extremity; Mathematical Model Simulation; Mathematics; Measures; Mechanics; Medical Device; Medical Device Safety; Medical center; Mentorship; Methods; Michigan; Mission; Modeling; Motion; Movement; Muscle; National Institute of Biomedical Imaging and Bioengineering; National Institute of Child Health and Human Development; Outcome; Pacemakers; Performance; Phase; Physics; Procedures; Process; Production; Program Development; Prosthesis; Public Health; Quality of life; Research; Residual state; Risk; Robotics; Safety; Side; Source; Specific qualifier value; System; Techniques; Testing; Thigh structure; Torque; Training; Universities; Validation; Walking; Work; ankle prosthesis; career; clinical application; cluster computing; computing resources; design; falls; human subject; improved; insight; kinematics; meetings; novel; patient mobility; powered prosthesis; programs; prosthesis wearer; rehabilitation research; simulation; sound; technology development; time interval; tool

Childcare supplement request for 1-F31-EB-032745-01. The information below is for the original submission. ABSTRACT Sit-stand transitions, the motions executed by individuals to stand up or sit down, are an important determinant of overall mobility and a common source of falls. Unilateral amputees using standard passive prostheses are further challenged by sit-stand transitions due to muscle and joint asymmetries they exhibit between the sound and amputated sides, often resulting in debilitating back pain. Powered knee-ankle prostheses can produce enough torque to assist meaningfully during sit-stand transitions and can meet design criteria such as producing smooth motion on the amputated side that matches the sound side. Controllers for these prostheses can be designed to allow user-driven control of the leg. However, the production of high torques not directly commanded by the user comes with increased risks. This is of particular concern because these legs must be adopted outside of controlled lab environments. Thus, any powered prosthesis must demonstrably meet design and safety criteria. While safety-critical medical devices, such as pacemakers, are subjected to extensive testing and validation procedures, there is no agreed- upon standard in the powered prosthetics field for how to define and measure safety. Prior work on sit-stand controllers has focused only on measuring a limited number of outcomes with respect to one design criterion on a small number of subjects, providing no guarantees about safety. The set of techniques known as formal verification provides powerful tools to reason about the behavior of systems that are composed of interacting mechanical, software, and biological modules. Given a model of a system, formal verification allows us to probe the system’s behavior over an infinite range of possibilities that cannot be replicated in the lab during a typical testing session. These methods can then guide real-world testing, and alert system designers to problematic regions of execution. In this project, I propose to apply formal verification techniques to design a volitional controller for sit-stand transitions with provable safety guarantees, using physics-based models and novel mathematical formulations of safety. The University of Michigan Robotics Institute is one of the top institutes of its kind in the US and provides an ideal environment and infrastructure for the successful completion of this research. The Robotics Institute gait lab has all of the necessary equipment needed for powered prosthesis research, including two state-of-the-art prosthetic legs, and access to advanced computational resources such as the Great Lakes high performance computing cluster. Drs. Umberger and Ozay have proven expertise relevant to the aims of this project, and will provide mentorship that will guide my research, my training, and the attainment of my career goals.

儿童保育补助申请：1-F31-EB-032745-01。下面的信息是为