HBV AND 1018 ISS VACCINE FORMULATION IN NEWBORN BABOONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项由两部分组成的研究。本实验的目的是首次在新生狒狒身上测试由免疫刺激DNA序列(1018ISS)与酵母-重组乙肝表面抗原(HBs)混合而成的乙肝疫苗的免疫原性。这项实验将有助于确定该疫苗是否能在新生狒狒中诱导抗体，并有助于确定1018 ISS的最佳剂量和最佳接种计划。这项研究将评估这种疫苗在狒狒中诱导对乙肝表面抗原的抗体反应的能力，相当于用于免疫人类婴儿的商业疫苗配方。从历史上看，成年狒狒已被证明是乙肝疫苗的良好模型，例如那些含有乙肝表面抗原和1018 ISS的疫苗。这些研究将有助于确定乙肝疫苗和ISS疫苗配方是否能在新生狒狒中引起相当于商业乙肝疫苗的反应，这将有助于为人类婴儿开发新的乙肝疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two-part study. The objective of this experiment is to test for the first time in newborn baboons the immunogenicity of a hepatitis B virus (HBV) vaccine formulation, consisting of immunostimulatory DNA sequences (1018 ISS) mixed with yeast-recombinant hepatitis B surface antigen (HBsAg). This experiment will help determine if this vaccine can elicit antibodies in newborn baboons, and help identify the optimal dose for 1018 ISS, and the optimal vaccination schedule. This study will evaluate the ability of this vaccine to induce an antibody response in baboons to HBsAg equivalent to a commercial vaccine formulation that is used to immunize human infants. Historically, adult baboons have shown to be a good model for HBV vaccines, such as those containing HBsAg plus 1018 ISS. These studies will help decide if the HBV and ISS vaccine formulation can elicit responses in newborn baboons equivalent to the commercial HBV vaccine, which will assist in the development of a new HBV vaccine for human infants.