ANTIGEN COMPARABILITY STUDY OF HBSAG + 1018 ISS

HBSAG 1018 ISS 的抗原可比性研究

• 批准号: 7562487
• 负责人: KATHLEEN M BRASKY
• 金额: $ 0.6万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562487
• 关键词: Antibody Formation; Antigens; Computer Retrieval of Information on Scientific Projects Database; DNA Sequence; Development; Funding; Grant; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Institution; Papio; Production; Recombinants; Research; Research Personnel; Resources; Societies; Source; Testing; United States National Institutes of Health; improved; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this experiment is to test the antibody responses of baboons to recombinant hepatitis B surface antigen (HBsAg) from a new production. HBsAg will be mixed with 1018 ISS an immunostimulatory DNA sequence that is known to induce a strong antibody response to HBsAg in baboons. This antigen comparability study will help determine if a new source of HBsAg will generate similar antibody responses to control antigen. This study may be beneficial to society since it will help in the development of a new/improved HBV vaccine.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本实验的目的是检测狒狒对来自新产品的重组B表面抗原（HBsAg）的抗体应答。 HBsAg将与1018 ISS（一种免疫刺激性DNA序列，已知可在狒狒中诱导对HBsAg的强烈抗体应答）混合。 该抗原可比性研究将有助于确定新的HBsAg来源是否会产生与对照抗原相似的抗体应答。 这项研究可能对社会有益，因为它将有助于开发新的/改进的HBV疫苗。