Hospital Medicine and Economics Centers for Education & Research for Therapeutics

描述(由申请人提供)：医院是密集使用药物、生物制品和设备的场所，对护理结果和成本都有重大影响。在过去十年中，医院护理开始发生重大变革，越来越多地使用临床信息系统和系统化的方法来提高安全性和质量，专门从事医院护理的医生人数迅速增加，其中包括重症医生和住院医生。在未来十年，新的基础和翻译技术，如药物基因组学和临床信息学，有望将个性化药物的新时代带到医院环境中。这使得有关有效和具有成本效益地使用医院疗法的知识的产生和传播变得尤为及时和重要。这项申请的目的是请求支持建立一个治疗学教育和研究中心(CERT)，专注于医院医学，主要方法重点是临床经济学。在CERT资金机会公告(FOA)中，这些领域被确定为高度优先领域。此外，还将把重点放在个性化医疗上，这是另一个高度优先的领域。医院医学和经济学CERT的总体目标将是创建一个强大的教育和研究基础设施，以生产和传播知识，以提高医院使用治疗方法的有效性和成本效益，包括药物、生物制品和设备。 医院医学和经济学CERT将设在芝加哥大学(UC)，该大学在医院医学研究和临床经济学以及个性化医学方面都拥有独特的资格。医院医学和经济学CERT还将受益于伊利诺伊大学芝加哥分校(UIC)药学院的参与，该学院已经通过不断发展的证据在这一领域与加州大学和AHRQ合作，为有效性(Decision)计划的决策提供信息。此外，医院医学和经济学CERT将受益于与Consorta，Inc.的合作，Consorta，Inc.是一个由500多家医院组成的全国性网络，并且能够利用由加州大学领导的先前存在的多中心医院医学研究小组(包括布里格姆和妇女医院、加州大学旧金山分校、爱荷华大学和威斯康星大学的研究人员)。医院医学和经济学CERT还将通过与医院医学学会的重要合作伙伴关系以及与国家舆论研究中心(NORC)的联系，获得全国性的范围和影响。

DESCRIPTION (Provided by the Applicant): Hospitals are the site of intensive use of drugs, biological products, and devices, with a major impact on both the outcome and cost of care. In the past decade, hospital care has begun a major transformation through the increasing use of clinical information systems and systematic approaches to improving safety and quality, and the rapid growth in the number of physicians specializing in hospital care, including intensivists and hospitalists. In the next decade, new basic and translational technologies, such as pharmacogenomics and clinical informatics, hold promise to bring a new era of personalized medicine to the hospital setting. This makes the production and dissemination of knowledge about the effective and cost-effective use of hospital therapeutics especially timely and important. The purpose of this application is to request support to establish a Center for Education and Research on Therapeutics (CERT) focused on hospital medicine with a major methodological focus on clinical economics. These are identified in the CERT Funding Opportunity Announcement (FOA) as high priority areas. In addition, there will be a secondary focus on personalized medicine, another high-priority area. The overall aim of the Hospital Medicine and Economics CERT will be to create a powerful education and research infrastructure to produce and disseminate knowledge to improve the effectiveness and cost-effectiveness of the use of therapeutics in hospitals, including drugs, biological products, and devices. The Hospital Medicine and Economics CERT will be based at the University of Chicago (UC), which has unique qualifications in both hospital medicine research and in clinical economics, as well as in personalized medicine. The Hospital Medicine and Economics CERT will also benefit from the participation of the University of Illinois-Chicago (UIC) School of Pharmacy, which already collaborates with UC and AHRQ in this area through the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) program. In addition, the Hospital Medicine and Economics CERT will benefit from collaboration with Consorta, Inc, a national network of over 500 hospitals, and the ability to draw upon a pre-existing multicenter hospital medicine research group led by UC (including investigators at Brigham and Women's Hospital, the University of California-San Francisco, the University of Iowa, and the University of Wisconsin). The Hospital Medicine and Economics CERT will also gain national scope and impact through an important partnership with the Society of Hospital Medicine, and through affiliation with the National Opinion Research Center (NORC).