Plant-Made Microbicides and Mucosal Vaccines for STIs
用于性传播感染的植物杀微生物剂和粘膜疫苗
基本信息
- 批准号:7491687
- 负责人:
- 金额:$ 126.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-01 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Exclusion of infectious agents from mucosal surfaces of the reproductive tract is a key objective of STI microbicides. The center will analyze mucosal antibodies as mechanisms of exclusion, and complimentary passive and active immunizations to achieve protective antibody concentrations in the female reproductive tract. A unique feature of this center will be the use of green plants as versatile highly cost-effective biomanufacturing systems for microbicides (e.g. antibody-based) and mucosal vaccines. Recognizing that access to STI public health programs will require low-cost and high capacity prevention technologies, this center utilizes the tools of plant biotechnology for biopharmaceutical production. This proposal addresses 4 specific areas of interest. Three scientific project areas are included in the AzBio Center.
Project 1 focuses on diversification, characterization and preclinical evaluation of human monoclonals (huMabs) protective against viral STIs. Project 2 focuses on creation and preclinical evaluation of mucosally targeted immunogens to achieve effective vaginal antibody concentrations against viral STls. Project 3 focuses on the clinical evaluation of passive and active immunization to achieve robust antibody concentrations in the female reproductive tract against viral STIs.
A Production Core will provide plant biotechnology services for Mabs and prototype vaccine production to support the three projects. An Administrative Core will oversee and coordinate all of the projects, including defining the regulatory map for clinical evaluation of the technologies, and strategic planning to blend emerging technologies to ensure that new biopharmaceuticals are accessible to the public health community. The outcomes of this study will define the safety and surrogate effectiveness of a layered system of plant-derived public health products for STIs.
描述(由申请人提供):从生殖道粘膜表面排除传染性病原体是STI杀菌剂的关键目标。该中心将分析粘膜抗体作为排斥机制,以及互补的被动和主动免疫,以达到女性生殖道的保护性抗体浓度。该中心的一个独特之处在于使用绿色植物作为杀菌剂(如基于抗体的)和粘膜疫苗的多功能高成本效益生物制造系统。认识到参与性传播感染公共卫生项目将需要低成本和高能力的预防技术,该中心利用植物生物技术工具生产生物制药。该提案涉及4个具体的兴趣领域。AzBio中心包括三个科学项目区。
项目成果
期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations.
- DOI:10.1007/s00299-011-1196-6
- 发表时间:2012-03
- 期刊:
- 影响因子:6.2
- 作者:Lai, Huafang;Chen, Qiang
- 通讯作者:Chen, Qiang
CCR5: From Natural Resistance to a New Anti-HIV Strategy.
- DOI:10.3390/v2020574
- 发表时间:2010-02
- 期刊:
- 影响因子:0
- 作者:Lopalco L
- 通讯作者:Lopalco L
Natural anti-CCR5 antibodies in HIV-infection and -exposure.
- DOI:10.1186/1479-5876-9-s1-s4
- 发表时间:2011-01-27
- 期刊:
- 影响因子:7.4
- 作者:Lopalco L
- 通讯作者:Lopalco L
Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine.
- DOI:10.1016/j.vaccine.2011.05.027
- 发表时间:2011-07-18
- 期刊:
- 影响因子:5.5
- 作者:Velasquez, Lissette S.;Shira, Samantha;Berta, Alice N.;Kilbourne, Jacquelyn;Medi, Babu M.;Tizard, Ian;Ni, Yawei;Arntzen, Charles J.;Herbst-Kralovetz, Melissa M.
- 通讯作者:Herbst-Kralovetz, Melissa M.
Norovirus Narita 104 virus-like particles expressed in Nicotiana benthamiana induce serum and mucosal immune responses.
尼古蒂亚纳本尼亚(Nicotiana benthamiana)表达的诺如病毒narita 104型病毒样颗粒会诱导血清和粘膜免疫反应。
- DOI:10.1155/2014/807539
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Mathew LG;Herbst-Kralovetz MM;Mason HS
- 通讯作者:Mason HS
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Charles Joel Arntzen其他文献
Charles Joel Arntzen的其他文献
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{{ truncateString('Charles Joel Arntzen', 18)}}的其他基金
Plant-derived vaccines against hepatitis C Cooperative *
植物源性丙型肝炎疫苗合作社*
- 批准号:
7287850 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Plant-derived vaccines against hepatitis C Cooperative *
植物源性丙型肝炎疫苗合作社*
- 批准号:
6988567 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Development of a vaccine for Ebola virus in plant system
在植物系统中开发埃博拉病毒疫苗
- 批准号:
6818636 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Development of a vaccine for Ebola virus in plant system
在植物系统中开发埃博拉病毒疫苗
- 批准号:
7493646 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Plant-derived vaccines against hepatitis C Cooperative *
植物源性丙型肝炎疫苗合作社*
- 批准号:
7489919 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Plant-derived vaccines against hepatitis C Cooperative *
植物源性丙型肝炎疫苗合作社*
- 批准号:
7682568 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Development of a vaccine for Ebola virus in plant system
在植物系统中开发埃博拉病毒疫苗
- 批准号:
7248753 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Development of a vaccine for Ebola virus in plant system
在植物系统中开发埃博拉病毒疫苗
- 批准号:
7032278 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
Plant-Based Production of Non-Envelope Antigens of HCV
基于植物的 HCV 非包膜抗原生产
- 批准号:
7013870 - 财政年份:2005
- 资助金额:
$ 126.41万 - 项目类别:
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