Animal Models Scientific Facilities Core

AM SFC的总体目标是在一个地点提供专门的设施、设备和 在动物模型中进行BSL3和选择病原体的研究的专业知识，这将促进 开发新的疫苗、治疗药物和其他人畜共患病病原体的生物防御产品。更多 具体地说，AM SFC的目标是建立和开发生物防御产品开发： 1.使用病毒和细菌病原体进行气雾剂吸入研究的设施和专门知识 高水平的遏制 2.利用啮齿动物进行节肢动物传播研究的设施和专门知识 较大的家养动物和野生动物 3.对研究生和博士后、技术人员和教职员工进行发展培训 以及利用气雾剂和媒介传播进行动物模型研究 动物模型核心内的工作人员将为多个层次的调查人员提供服务。在一些 在案例中，核心人员将在实验设计方面提供实质性协助，并负责所有 动物实验的各个方面，包括病原体的运送、监测和采样(例如血液) 以及实施安乐死和身体解剖。这种服务模式将最适用于 来自其他机构和涉及私营公司的项目的调查人员。服务的另一端 光谱将在需要时提供援助，特别是在气雾剂和病媒传播方面 病原体的数量。在项目的第一年，我们将在小鼠身上建立和表征气溶胶模型。 三种病原体：图拉氏方济氏菌LVS株、拉克罗斯脑炎病毒和狂犬病病毒。 这三种病原体都是重要的Bt制剂的模型，这项工作将允许AM中的人员 证监会将优化新设施的使用，为其将 支持。

The overall goal of the AM SFC is to provide in one location the specialized facilities, equipment, and expertise to conduct research on BSL3 and Select Agent pathogens in animal models, which will promote the development of new vaccines, therapeutics, and other biodefense products for zoonotic agents. More specifically, the aims of the AM SFC are to establish and exploit for biodefense product development: 1. Facilities and expertise for aerosol inhalation studies using viral and bacterial pathogens that require high levels of containment 2. Facilities and expertise for studies involving arthropod-borne transmission using rodents as well as larger domestic animals and wildlife 3. Training to graduate and post-doctoral students, technicians and faculty members for development and implementation of animal model studies using aerosol and vector-borne transmission Personnel within the Animal Model Core will provide services to investigators at multiple levels. In some cases, personnel in the core will assist substantively in experimental design and be responsible for all aspects of animal experimentation, including delivery of the pathogen, monitoring and sampling (e.g. blood) from animals, and performing euthanasia and necropsies. This mode of service will be most applicable to investigators from other institutions and to projects involving private companies. The other end of the service spectrum will be to provide assistance as needed, especially in regard to aerosol and vector-borne delivery of pathogens. During the first year of the project, we will establish and characterize aerosol models in mice of three pathogens: the LVS strain of Francisella tularensis, LaCross encephalitis virus and rabies virus. These three pathogens are all models for important BT agents, and this work will allow personnel in the AM SFC to optimize the use of the new facility in preparation for the large number of specific projects that it will support.