Animal Models Scientific Facilities Core

AM SFC的总体目标是在一个地点提供专业设施、设备和 在动物模型中对BSL 3和选择性病原体进行研究的专业知识，这将促进 开发新的疫苗、治疗剂和其他针对人畜共患病病原体的生物防御产品。更 具体地说，AM SFC的目标是为生物防御产品开发建立和利用： 1.使用病毒和细菌病原体进行雾化吸入研究的设施和专业知识， 更高级别的遏制 2.利用啮齿动物进行节肢动物传播研究的设施和专门知识，以及 大型家畜和野生动物 3.对研究生和博士后学生、技术人员和教员进行发展培训 利用气溶胶和病媒传播进行动物模型研究 动物模型中心的工作人员将为研究者提供多层次的服务。在一些 在某些情况下，核心人员将实质性地协助实验设计，并负责所有 动物实验的各个方面，包括病原体的递送、监测和取样（例如血液） 从动物身上，并进行安乐死和尸检。这种服务模式将最适用于 其他机构的调查人员以及涉及私营公司的项目。服务的另一端 特别是在气溶胶和病媒传播方面， 病原体。在项目的第一年，我们将建立和表征小鼠气溶胶模型 三种病原体：土拉热弗朗西丝氏菌LVS株、拉克罗斯脑炎病毒和狂犬病病毒。 这三种病原体都是重要的BT剂的模型，这项工作将使AM中的人员 证监会优化新设施的使用，为大量的具体项目做好准备， 支持.

The overall goal of the AM SFC is to provide in one location the specialized facilities, equipment, and expertise to conduct research on BSL3 and Select Agent pathogens in animal models, which will promote the development of new vaccines, therapeutics, and other biodefense products for zoonotic agents. More specifically, the aims of the AM SFC are to establish and exploit for biodefense product development: 1. Facilities and expertise for aerosol inhalation studies using viral and bacterial pathogens that require high levels of containment 2. Facilities and expertise for studies involving arthropod-borne transmission using rodents as well as larger domestic animals and wildlife 3. Training to graduate and post-doctoral students, technicians and faculty members for development and implementation of animal model studies using aerosol and vector-borne transmission Personnel within the Animal Model Core will provide services to investigators at multiple levels. In some cases, personnel in the core will assist substantively in experimental design and be responsible for all aspects of animal experimentation, including delivery of the pathogen, monitoring and sampling (e.g. blood) from animals, and performing euthanasia and necropsies. This mode of service will be most applicable to investigators from other institutions and to projects involving private companies. The other end of the service spectrum will be to provide assistance as needed, especially in regard to aerosol and vector-borne delivery of pathogens. During the first year of the project, we will establish and characterize aerosol models in mice of three pathogens: the LVS strain of Francisella tularensis, LaCross encephalitis virus and rabies virus. These three pathogens are all models for important BT agents, and this work will allow personnel in the AM SFC to optimize the use of the new facility in preparation for the large number of specific projects that it will support.