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Animal Models Core

动物模型核心

基本信息

批准号：
8375728
负责人：
Richard Arnold Bowen
金额：
$ 26.03万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8375728
关键词：
Aerosols Animal Disease Models Animal Experiments Animal Model Animals Antibiotic Therapy Area Autopsy Biological Assay Blood specimen Budgets Canis familiaris Clinical Clinical Chemistry Clinical Trials Clinical Trials Design Collection Complex Containment Data Data Analyses Development Diagnostic Diagnostic tests Disease Domestic Animals Dose Emerging Communicable Diseases Evaluation Exposure to Family suidae Fee Schedules Fee-for-Service Plans Funding Goals Goat Government Hematology Human Human Resources Immune response Immunologics Income Institution Intervention Lung Mission Modeling Monitor Morbidity - disease rate Mus National Institute of Allergy and Infectious Disease Non-Rodent Model Organ Pathogenesis Pathologic Performance Pharmaceutical Preparations Phase I Clinical Trials Positioning Attribute Preparation Reagent Research Research Personnel Resources Rodent Model Route Sampling Serum Services Testing Therapeutic Therapeutic Agents Therapy Clinical Trials Time Training United States National Institutes of Health Vaccine Adjuvant Vaccines Viral Work Writing animal rule antimicrobial drug base biodefense design good laboratory practice immunoregulation mortality pathogen product development programs research clinical testing research study response tool vaccine efficacy

项目摘要

The primary mission of the Animal Models Core (Core C) is to conduct animal challenge trials in support of studies by investigators within the RMRCE, at other RCEs and with other governmental, private and academic institutions. These services will be tailored to the needs of the investigator and program, ranging from simple morbidity and mortality experiments, to more complex studies involving aerosol challenges, intense clinical evaluation (i.e. blood sampling over time, telemetric monitoring, hematology), necropsy, histopathologic evaluation and organ pathogen loads. The work will be fee-for-service to investigators, with different fee schedules for RCE and US government investigators versus those from non-RCE academic institutions and commercial entities. In addition to this primary focus on service, Core C personnel will: 1) Assist investigators in the design of appropriate animal experiments, including writing the animal use, select agent and animal budget portions of proposals. This is viewed as a valuable and important service which will ultimately augment program income and contribute to the biodefense effort. 2) Establish new, and enhance existing, rodent models in response to or anticipation of investigator needs. One goal for Year 1 will be to establish, for selected bacterial pathogens, the maximum interval postchallenge at which initiation of high-dose (relevant) antibiotic therapy will allow survival; these data will provide reference points to assist in designing and conducting trials to evaluate therapeutic agents to be applied post-exposure. Another example of enhancing current models will be to characterize the hematologic and clinical chemistry alterations associated with disease pathogenesis; again, this will be valuable in evaluating efficacy of pharmacologic or immunologic interventions. 3) Promote the use of non-rodent models for certain pathogens. Such models could provide large quantities of serum and other samples as reference reagents and to test diagnostic platforms, to provide natural host bases for vaccine and therapeutic trials, and to allow realistic ICU-type monitoring in trials designed to evaluate therapies for human use. Core C is uniquely positioned among RCEs to provide such capabilities. Core C will support all three of the RMRCE Integrated Research Foci on Immunomodulation, Adjuvants and Vaccines (IRF 1), Bacterial Therapeutics (IRF 2), and Viral Therapeutics (IRF 3). Its resources will be utilized by RPs 1.5, 1.6, 1.7, 1.8, 2.3, 2.6, 2.7, 3.3, 3.5 and 3.6.

动物模型核心（Core C）的主要任务是开展动物挑战试验，以支持