Northeast Biodefense Center

美国东北部极易受到新出现的传染病和恐怖主义的影响。与 西尼罗河病毒的爆发，世界贸易中心的悲剧，以及随后的炭疽袭击，第二区 调动其丰富的生物医学研究资源， 生物防御议程第二区域机构将建立一个区域卓越中心（RCE）， 生物防御和新兴传染病研究。这个财团，东北生物防御中心 (NBC)，将由纽约超过25个学术和研究机构的调查人员组成， 新泽西州，康涅狄格州，马萨诸塞州和波多黎各。NBC将与州、联邦和 当地政府机构和实验室，以及生物技术和制药公司。重大基础 和转化研究计划将在六个主题领域进行：1）B细胞相关的预防和 治疗学; 2）细菌发病机理和治疗学; 3）疫苗平台; 4）病毒发病机理和治疗学 治疗学; 5）天花疫苗：临床、免疫和病毒结果; 6）病原体检测和 诊断。这些程序将与提供信息学，蛋白质组学， 蛋白质表达、单克隆抗体、动物模型以及给药。每个研究 该计划将整合和加强几位有成就的调查人员的工作，并将重点关注选定的 包括A.炭疽杆菌，鼠疫耶尔森氏菌，土拉热弗朗西丝氏菌，鼻疽伯克霍尔德氏菌， 葡萄球菌肠毒素B、痘病毒和引起出血热或脑炎的病毒。 由于该区域的重要性、全国广播公司成员的专业知识， 获得独特的资源，如Plum Island Animal Disease Center和调查人员网络， 比较医学的临床医生将建立简化的技术转让程序， 促进向疫苗、治疗剂和诊断剂行业的交付。NBC的平移臂 从研究天花疫苗开始，并将发展该地区人类疫苗的基础设施 审判将制定培训计划，通过支持新的生物防御研究项目， 调查员、高级调查员和支助人员。紧急应变计划已 发展的目的是迅速调整全国广播公司的活动，并提供设施，包括核心和科学支持， 在生物防御紧急情况下的一线响应者。

The northeastern United States is highly vulnerable to emerging infectious diseases and terrorism. With the outbreak of West Nile virus, the World Trade Center tragedy, and subsequent anthrax attacks, Region II has the experience and resolve to mobilize its rich resources in biomedical research to advance the nation's biodefense agenda. Region II institutions will establish a Regional Center of Excellence (RCE) for Biodefense and Emerging Infectious Disease Research. This consortium, the Northeast Biodefense Center (NBC), will comprise investigators at more than 25 academic and research institutions in New York, New Jersey, Connecticut, Massachusetts and Puerto Rico. The NBC will have strong links to state, federal and local government agencies and laboratories, as well as biotech and pharmaceutical companies. Major basic and translational research programs will be pursued in six thematic areas: 1) B-Cell Related Prophylaxis and Therapeutics; 2) Bacterial Pathogenesis and Therapeutics; 3) Vaccine Platforms; 4) Viral Pathogenesis and Therapeutics; 5) Smallpox Vaccine: Clinical, Immune, and Viral Outcomes; 6) Pathogen Detection and Diagnostics. These programs wil_ intersect with cores that provide support in Informatics, Proteomics, Protein Expression, Monoclonal Antibodies, Animal Models, as well as Administration. Each research program will integrate and intensify the work of several accomplished investigators and will focus on select agents and toxins including A. Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Staphylococcus enterotoxin B, pox viruses, and viruses that cause hemorrhagic fever or encephalitis. Zoonotic diseases will be emphasized due to significance in this region, expertise of NBC members, and access to unique resources such as Plum Island Animal Disease Center and networks of investigators and clinicians in comparative medicine. Streamlined technology transfer procedures will be established to facilitate delivery to industry of vaccines, therapeutics, and diagnostics. The translational arm of the NBC has begun with a study of smallpox vaccination and will develop the region's infrastructure for human vaccine trials. Training programs will be established to promote biodefense research objectives by supporting new investigators, senior investigators, and support personnel. An emergency response plan has been developed to rapidly realign the NBC's activities and provide facilities, including cores and scientific support, to first line responders in the event of a biodefense emergency.