SERCEB Southeast Regional Centers of Excellence for Bio*

SERCEB 东南区域生物卓越中心*

• 批准号: 7560473
• 负责人: PHILIP Frederick SPARLING
• 金额: $ 1018.97万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7560473
• 关键词: SERCEB; Southeast; Regional; Centers; Excellence

The Region IV RCE is the Southeastern Regional Center of Excellence in Emerging Infections and Biodefense or SERCEB. SERCEB has unified the major research institutions in Region IV, and has established collaborations with Oak Ridge National Laboratory in Oak Ridge, TN, the Centers for Disease Control and Prevention, Atlanta, GA, and the Vaccine Research Center at the NIH. The goals of SERCEB are to develop new vaccines, therapeutics, and diagnostics to better protect the nation against potential bioterrorist threats. This will be accomplished by interdisciplinary and collaborative research using cutting edge science. A major research focus is on novel vaccine development for orthopoxviruses, Bacillus anthracis and Yersinia pestis, with each program led by a team of internationally renowned investigators (Programs 1,3,4, and 5). Two immunology programs will interact synergistically with the vaccine programs: Program 6 will develop strategies to modulate innate immunity to enhance immune responses to select agents and vaccines, and Program 7 will develop strategies to enhance adaptive T and B immune responses to select agents and vaccines. New drug development will include rapid screening of existing compounds and development of entirety novel drugs against orthopoxviruses (Program 2), as well as therapeutics directed at innate immunity (Program 6), Anthrax (Program 5), and Y. pestis (Program 4). Multiple sophisticated cores will provide powerful assistance for development of vaccines, drugs, and diagnostics. SERCEB also will help to bring new investigators to the biodefense effort, through a combination of educational programs, support of innovative new projects, and synergistic interactions among some of the best investigators in relevant research in the nation.

第四区RCE是东南部地区新兴市场卓越中心 感染和生物防御或SERCEB。SERCEB将主要的研究机构统一在 第四地区，并与橡树岭国家实验室建立了合作关系， TN、疾病控制和预防中心、佐治亚州亚特兰大和疫苗研究 在国立卫生研究院的中心。SERCEB的目标是开发新的疫苗、疗法和 诊断，以更好地保护国家免受潜在的生物恐怖威胁。这将是 通过使用尖端科学的跨学科和协作研究完成。一位少校 研究重点是针对正痘病毒、炭疽芽孢杆菌和 鼠疫耶尔森氏菌，每个项目都由一组国际知名的调查人员领导 (方案1、3、4和5)。两个免疫学项目将与疫苗协同作用 计划：计划6将制定调整天然免疫以增强免疫的策略 对选定的试剂和疫苗的反应，以及计划7将制定战略，以加强 对选定的制剂和疫苗的适应性T和B免疫反应。新药开发将 包括快速筛选现有化合物和开发针对 正痘病毒(计划2)，以及针对先天免疫的疗法(计划6)， 炭疽病(计划5)和鼠疫杆菌(计划4)。多个复杂的内核将提供强大的 为疫苗、药物和诊断的开发提供援助。SERCEB还将帮助带来 新的调查人员对生物防御的努力，通过教育计划的组合，支持 创新的新项目，以及一些最好的研究人员之间的协同互动 国内的相关研究。