MRCE for Biodefense and Emerging Infectious Diseases

中西部地区生物防御和新发传染病研究卓越中心 (MRCE)是一个由中西部领先机构组成的联盟，将为生物防御研究和培训提供服务 对第七区以及俄亥俄州部分地区的需求。MRCE的创始成员是华盛顿 圣路易斯大学(行政核心所在地)，凯斯韦斯特储备大学，圣路易斯 中西部研究院和密苏里大学。MRCE的主要目标是 是利用来自最好机构的杰出科学家专注于生物防御中的临床问题 和新发传染病。我们的目标是研究将对国家的 公共卫生，并将为强有力的生物防御努力提供科学基础。三年的战略规划 MRCE专注于在痘病毒生物学方面的综合多机构努力。的连词 在天花疫苗的临床研究和基础研究方面的现有计划非常强大 痘病毒和对病毒感染的先天免疫，将使我们能够回答关于 牛痘感染的生物学以及接种天花疫苗的风险。我们的第二个节目聚焦于瘟疫， 并将利用遗传学和结构生物学的最新平台来研究耶尔森氏菌的发病机制 并设计了一类新的抗菌剂--杀菌剂，用于治疗鼠疫。这个 MRCE努力的支柱是旨在服务于第七区域和 这个国家。最重要的核心是华盛顿大学基因组测序中心，即 美国最大的测序中心。MRCE战略计划将巩固高点 为MRCE的所有区域卓越中心提供吞吐量测序和基因分型服务， 从而显著节省了成本。最后，MRCE将领导招募新调查人员的努力 生物防御的临床和基础研究，并培训他们如何安全可靠地进行这项研究 通过三个不同的职业发展计划，包括一个独一无二的奖学金计划，将 培养生命科学博士后，使其成为生物安全官员。MRCE的定位是独特的 通过一项特殊计划服务于第七区和全国，该计划解决了最直接和最 迫切的国家生物防御需求。

The Midwest Regional Center for Excellence in Biodefense and Emerging Infectious Diseases Research (MRCE) is a consortium of leading Midwest institutions that will serve the biodefense research and training needs for Region VII as well as parts of Ohio. The founding members of the MRCE are Washington University in St. Louis (site of the administrative core), Case Westem Reserve University, St. Louis University, the Midwest Research Institute, and the University of Missouri. The major objective of the MRCE is to harness outstanding scientists from the best institutions to focus on cdtical clinical issues in biodefense and emerging infectious diseases. Our goal is research that will have an immediate impact on the nation's public health, and will provide the scientific base for a strong biodefense effort. The Strategic Plan for the MRCE centers on a comprehensive multi-institutional effort on the biology of poxviruses. The conjunction of extraordinarily strong existing programs in clinical research on smallpox vaccination and basic research on poxviruses and innate immunity to viral infections, will allow us to answer the critical questions about the biology of vaccinia infection, and the risks of smallpox vaccination. Our second program focuses on plague, and will use state of the art platforms in genetics and structural biology to study the pathogenesis of Yersinia pestis, and design a new class of antibacterial agents, the pilicides, for the treatment of plague. The backbone of the MRCE effort are Core Facilities designed to serve the biodefense needs of Region VII and the nation. Foremost among the Cores is the Washington University Genome Sequencing Center, the largest sequencing center in the United States. The MRCE Strategic Plan will consolidate the high throughput sequencing and genotyping services for all the Regional Centers for Excellence at the MRCE, resulting in significant cost savings. Finally, the MRCE will lead the effort to recruit new investigators to clinical and basic research in biodefense and train them in how to conduct this research safely and securely through three distinct Career Development Programs, including a one-of-a-kind fellowship program that will train postdoctoral fellows in the life sciences to become biosafety officers. The MRCE is uniquely positioned to serve Region VII and the nation through an exceptional program that addresses the most immediate and urgent national biodefense needs.