PROTECTIVE IMMUNITY TO ENTAMOEBA HISTOLYTICA INFECTION

本研究计划的原生动物寄生虫E。溶组织菌具有 集中在分离和表征的表面抗原， 与宿主肠细胞相互作用的阿米巴，在了解 免疫应答E.组织溶解性感染，并开发重组 以抗原为基础的疫苗来预防阿米巴病。 许多这些研究 利用了富含丝氨酸的E.溶组织蛋白（SREHP），一种新的 阿米巴表面蛋白 scid小鼠模型的研究进展 以及3个重组E. 溶组织抗原以研究对阿米巴感染的保护性免疫， 并研制预防阿米巴感染的疫苗。

This research program on the protozoan parasite E. histolytica has focused on the isolation and characterization of surface antigens of amebae that interact with host intestinal cells, on understanding the immune response to E. histolytical infection, and developing recombinant antigen-based vaccines to prevent amebic disease. Many of these studies have utilized the serine rich E. histolytica protein (SREHP), a novel surface protein of amebae. The recent development of a scid mouse model of amebic infection, and the cloning and expression of 3 recombinant E. histolytica antigens to study protective immunity to amebic infection, and to develop vaccines to prevent amebic infection.