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PROTECTIVE IMMUNITY TO ENTAMOEBA HISTOLYTICA INFECTION

PROTECTIVE IMMUNITY TO ENTAMOEBA HISTOLYTICA INFECTION
对溶组织内阿米巴感染的保护性免疫
批准号：
2057405
负责人：
SAMUEL L. STANLEY
金额：
$6.35万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-09-01 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/2057405
关键词：
Entamoeba histolytica SCID mouse amebiasis baboons cellular immunity cytokine enzyme linked immunosorbent assay flow cytometry fluorescence microscopy gerbil /jird host organism interaction immunological substance interferon gamma intracellular parasitism parasitic gastrointestinal disorder parasitic liver disorder pathologic process protozoal antigen protozoal vaccine tumor necrosis factor alpha

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中文摘要
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英文摘要
This research program on the protozoan parasite E. histolytica has focused on the isolation and characterization of surface antigens of amebae that interact with host intestinal cells, on understanding the immune response to E. histolytical infection, and developing recombinant antigen-based vaccines to prevent amebic disease. Many of these studies have utilized the serine rich E. histolytica protein (SREHP), a novel surface protein of amebae. The recent development of a scid mouse model of amebic infection, and the cloning and expression of 3 recombinant E. histolytica antigens to study protective immunity to amebic infection, and to develop vaccines to prevent amebic infection.
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An Animal Biosafety Level 3 Laboratory for Stony Brook University
MRCE Administrative Core
  • 批准号：
    7641628
  • 项目类别：
  • 资助金额：
    $55.86万
  • 财政年份：
    2008
  • 负责人：
    SAMUEL L. STANLEY
  • 依托单位：
    WASHINGTON UNIVERSITY
Overall Career Development
  • 批准号：
    7641691
  • 项目类别：
  • 资助金额：
    $66.24万
  • 财政年份：
    2008
  • 负责人：
    SAMUEL L. STANLEY
  • 依托单位：
    WASHINGTON UNIVERSITY
Immunogenetics of Smallpox Vaccination
  • 批准号：
    7641580
  • 项目类别：
  • 资助金额：
    $31.99万
  • 财政年份：
    2008
  • 负责人：
    SAMUEL L. STANLEY
  • 依托单位：
    WASHINGTON UNIVERSITY
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