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ZINC HOMEOSTASIS AND PULMONARY ENDOTHELIAL CELL INJURY

ZINC HOMEOSTASIS AND PULMONARY ENDOTHELIAL CELL INJURY
锌稳态与肺内皮细胞损伤
批准号：
7659607
负责人：
Bruce Robert Pitt
金额：
$36.59万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-08-15 至 2011-06-30
来源：
https://reporter.nih.gov/project-details/7659607
关键词：
AccountingAdenovirus VectorAffectAnimalsAntioxidantsApoptosisApoptosis InhibitorApoptoticArginineBinding ProteinsBiochemical ProcessBreathingCatalysisCell NucleusCellsChelating AgentsChemistryChimera organismConfocal MicroscopyControl AnimalCytoplasmDifferentiation and GrowthDiseaseEndothelial CellsEndotheliumEndotoxinsEnzymesEstersExposure toFloorFluorescence Resonance Energy TransferFree RadicalsFunctional disorderGene ExpressionGenomeGreen Fluorescent ProteinsHeavy MetalsHomeostasisHumanHydrogen PeroxideHyperoxiaImageInfectionIonsIronLinkLungMaintenanceMediatingMessenger RNAMetallothioneinMetalsModificationMolecularMusNecrosisNitric OxideNitrogenNuclearNuclear Localization SignalOxidantsOxidation-ReductionOxygenPathogenesisPathway interactionsPharmacologyPhysiologicalPhysiological ProcessesPlasmaPlasmidsPolymersProcessProductionProteinsRadioactiveRelative (related person)ReporterReportingResistanceRoleScienceSignal TransductionSiteSodiumSomatic Gene TherapyStimulusStructural ProteinSuperoxidesSystemToxic effectTrace metalTransgenic MiceUniversitiesVascular EndotheliumZincantibody conjugatecell injurychelexcofactoremission spectroscopyexpression vectormutantnitrosative stressoverexpressionpreconditioningprogramspromoterpyrithioneresponsetert-Butylhydroperoxidetranscription factorzinc thioneinzinc-binding proteinzinquin

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University of Pittsburgh Department of Pharmacology 13th Floor Biomedical Science Tower, Pittsburgh,PA 15261
期刊论文(12)
专著(0)
科研奖励(0)
会议论文
S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate.
DOI： 10.1152/ajplung.00233.2009
发表时间： 2010-07
期刊： American journal of physiology. Lung cellular and molecular physiology
影响因子： --
作者： [W. Szczepaniak;B. Pitt;B. McVerry]
通讯作者： W. Szczepaniak;B. Pitt;B. McVerry
Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.
信号转导器和转录激活剂 1 (STAT1) 对于人气道上皮细胞中基因诱导的铬沉默至关重要。
DOI： 10.1093/toxsci/kfp084
发表时间： 2009
期刊： Toxicological sciences : an official journal of the Society of Toxicology
影响因子： --
作者： [Nemec,AntoniaA, Barchowsky,Aaron]
通讯作者： Barchowsky,Aaron
LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells.
DOI： 10.1152/ajplung.00376.2010
发表时间： 2011-01
期刊： American journal of physiology. Lung cellular and molecular physiology
影响因子： --
作者： [Kalidasan Thambiayya;K. Wasserloos;Zhen-tai Huang;V. Kagan;C. S. St Croix;B. Pitt]
通讯作者： Kalidasan Thambiayya;K. Wasserloos;Zhen-tai Huang;V. Kagan;C. S. St Croix;B. Pitt
Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.
金属硫蛋白诱导的锌分配加剧高氧急性肺损伤。
DOI： 10.1152/ajplung.00243.2012
发表时间： 2013
期刊： American journal of physiology. Lung cellular and molecular physiology
影响因子： --
作者： [Lee,Sang-Min, McLaughlin,JosephN, Frederick,DanielR, Zhu,Lin, Thambiayya,Kalidasan, Wasserloos,KarlaJ, Kaminski,Iris, Pearce,LindaL, Peterson,Jim, Li,Jin, Latoche,JosephD, PeckPalmer,OctaviaM, Stolz,DonnaBeer, Fattman,CherylL, Alcor]
通讯作者： Alcor
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University of Pittsburgh: Short-Term Educational Experiences for Research (PITT-S
University of Pittsburgh: Short-Term Educational Experiences for Research (PITT-S
University of Pittsburgh: Short-Term Educational Experiences for Research (PITT-S
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