Microglial paralysis in post-stroke neurodegeneration: help or hindrance?

中风后神经变性中的小胶质细胞麻痹：帮助还是阻碍？

• 批准号: nhmrc : GNT1142861
• 负责人: A/Pr Frederick Walker
• 金额: $ 51.24万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microglial-paralysis-post-help-hindrance/1348481
• 关键词: Microglial; paralysis; post; stroke; neurodegeneration

Dementia and cognitive decline may occur months or years after a stroke, associated with delayed loss of brain cells in different brain regions. We recently discovered that the cells responsible for protection and repair of brain, called microglia, become paralysed in these regions. We will use a live-imaging microscope to determine whether the microglial paralysis causes brain cell death. We will also determine if a commonly used stroke prevention drug can worsen the microglial paralysis.

痴呆症和认知能力下降可能在中风后数月或数年发生，与大脑不同区域的脑细胞延迟损失有关。我们最近发现，负责保护和修复大脑的小胶质细胞，在这些区域瘫痪了。我们将使用活体成像显微镜来确定小胶质麻痹是否会导致脑细胞死亡。我们还将确定一种常用的中风预防药物是否会加重小神经胶质麻痹。