Microglial paralysis in post-stroke neurodegeneration: help or hindrance?

痴呆和认知能力下降可能发生在中风后数月或数年，与不同脑区脑细胞的延迟损失有关。我们最近发现，负责保护和修复大脑的细胞，称为小胶质细胞，在这些区域变得瘫痪。我们将使用活体成像显微镜来确定小胶质细胞麻痹是否会导致脑细胞死亡。我们还将确定一种常用的中风预防药物是否会加重小胶质细胞麻痹。

Dementia and cognitive decline may occur months or years after a stroke, associated with delayed loss of brain cells in different brain regions. We recently discovered that the cells responsible for protection and repair of brain, called microglia, become paralysed in these regions. We will use a live-imaging microscope to determine whether the microglial paralysis causes brain cell death. We will also determine if a commonly used stroke prevention drug can worsen the microglial paralysis.