Stroke induced disturbances in glymphatic clearance: implications for brain repair?

我们已经有了一个了不起的发现，中风后大脑清除废物蛋白质的能力显著受损。这可能对痴呆症的发展和中风后晚期思维的温和变化有重要的影响。我们已经有了一些关于潜在机制的线索。在这个项目中，我们将进一步研究这些机制及其对大脑的影响，并发展我们对扭转清除问题的潜在方法的理解，以开发治疗方法。

We have made a remarkable discovery that the ability of the brain to clear waste proteins is significantly impaired after stroke. This may have important implications for development of dementia and milder changes in thinking late after stroke. We already have some clues regarding potential mechanisms. In this project we will further investigate these mechanisms and their effects on the brain and develop our understanding of potential ways to reverse the clearance problem to develop treatments.