Stroke induced disturbances in glymphatic clearance: implications for brain repair?

中风引起的类淋巴清除紊乱：对大脑修复的影响？

• 批准号: nhmrc : 1142862
• 负责人: A/Pr Frederick Walker
• 金额: $ 33.24万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stroke-induced-disturbances-brain-repair/1319800
• 关键词: Stroke; induced; disturbances; glymphatic; clearance

We have made a remarkable discovery that the ability of the brain to clear waste proteins is significantly impaired after stroke. This may have important implications for development of dementia and milder changes in thinking late after stroke. We already have some clues regarding potential mechanisms. In this project we will further investigate these mechanisms and their effects on the brain and develop our understanding of potential ways to reverse the clearance problem to develop treatments.

我们有了一个显着的发现，即中风后大脑清除废物蛋白质的能力显着受损。这可能对痴呆症的发展以及中风后期思维的轻微变化具有重要意义。我们已经掌握了一些关于潜在机制的线索。在这个项目中，我们将进一步研究这些机制及其对大脑的影响，并加深我们对扭转清除问题的潜在方法的理解，以开发治疗方法。