Characterisation and modelling of schizophrenia-associated dysregulation of miR-137 expression

我们已经确定了精神分裂症患者大脑皮层中非编码microRNA基因表达的突变相关变化。这个被称为MIR137的基因通过抑制数百个靶基因发挥作用，因此对精神分裂症具有重要意义。该项目将确定影响MIR137表达的遗传机制，并确定这种变化在精神分裂症背景下的生物学和行为学意义。

We have identified mutation-associated changes in the expression of a non-coding microRNA gene in the cerebral cortex in schizophrenia. This gene, known as MIR137, functions by repressing hundreds of target genes and therefore has major implications for schizophrenia. The project will identify the genetic mechanism affecting the expression of MIR137, and determine the biological and behavioural implications of this change in the context of schizophrenia.