A new target for antidepressant treatment: microglia mediated neuroinflammation

抗抑郁治疗的新靶点：小胶质细胞介导的神经炎症

• 批准号: nhmrc : 1003068
• 负责人: A/Pr Frederick Walker
• 金额: $ 23.98万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-target-antidepressant-mediated-neuroinflammation/108890
• 关键词: new; target; antidepressant; treatment; microglia

Depression is the leading cause of non-fatal disease burden in Australia. Unfortunately, current antidepressants do not provide adequate levels of relief and it is accepted that we need to develop more effective treatments. We have recently shown that a drug that reduces inflammation in the brain also reduces depression-like symptoms. This project aims to extend upon these extremely promising findings, in the hope of developing a new and more effective generation of antidepressants.

抑郁症是澳大利亚非致命疾病负担的主要原因。不幸的是，目前的抗抑郁药不能提供足够的缓解水平，我们需要开发更有效的治疗方法。我们最近发现，一种减少大脑炎症的药物也可以减少抑郁样症状。该项目旨在扩展这些非常有希望的发现，希望开发新一代更有效的抗抑郁药。