Murine models to test parasite products as cures for Inflammatory Bowel Disease

小鼠模型测试寄生虫产品治疗炎症性肠病的效果

• 批准号: 7618005
• 负责人: LINDA S. MANSFIELD
• 金额: $ 10.82万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618005
• 关键词: Animal Model; Animals; Award; Campylobacter jejuni; Chronic; Clinical Parasitology; Coccidia; Contracts; Cyst; Diagnostic; Disease; Doctor of Philosophy; Enteral; Enterobacteriaceae; Food; Fostering; Funding; Goals; Grant; Health; Human; Infection; Inflammation; Inflammatory Bowel Diseases; Institutes; Interleukin-10; Knockout Mice; Leadership; Mediating; Medicine; Mentors; Michigan; Microbiology; Modality; Modeling; Mus; Parasites; Pennsylvania; Population; Procedures; Property; Qualifying; Research; Research Personnel; Research Training; Running; Sarcocystis; Testing; Time; Training; Trichuris; United States National Institutes of Health; Universities; Veterinarians; career; comparative; enteric pathogen; enteritis; graduate student; mouse model; pathogen; post-doctoral training; programs; success; waterborne

DESCRIPTION (provided by applicant): Investing in enhancement of Dr. Mansfield's mouse model activities will result in progress in understanding and treating inflammatory disease of the bowel resulting from enteric pathogens and in fostering veterinarians to enter the research arena. Dr. Mansfield graduated from a V.M.D., Ph.D. program in Biomedical Graduate Studies at the University of Pennsylvania in 1990 and finished postdoctoral training at the Animal Parasite Institute in 1994. Currently, she is 11 years from her training, thus, qualifying as a Mid-Career investigator. Her training and research career were spent developing animal models of human and animal infectious enteric diseases. From 1990-2003, she focused on finding naturally occurring animal models for Campylobacter jejuni and Cyst forming coccidia (Sarcocystis neurona, etc.) with the long-term goal to convert these to mouse models. In 2002-04, she successfully achieved funding to implement mouse models for these pathogens and, thus, shifted her focus within comparative medicine from large animal models of these human and animal enteric diseases to murine models. Recent funded and pending grants on mouse pathobiology document this career shift. Simultaneously, she requested relief from administrative duties running the Clinical Parasitology Section of the Diagnostic Center for Population and Animal Health. Caseloads had burgeoned under her leadership from 1500 to >10,000/year placing increasing demands on time for research and mentoring. Dr. Mansfield seeks Career Award funds to enhance her program in mouse pathobiology especially to pursue projects in the funded NIH contract "Michigan State University Microbiology Research Unit: Food and Waterborne Integrated Research Network". These Career Award funds would enable new mouse models including, 1)"Murine models of C. jejuni colonization and enteritis" to determine mechanisms by which C. jejuni and other enteric bacteria stimulate chronic inflammation in the gut, and 2)"Worm mediated control of inflammatory Bowel Disease" to determine immunomodulatory properties of defined parasitic products from Trichuris on colonic inflammation (spontaneous and pathogenmediated). These mouse models will serve as the first modality for testing select parasites and their molecules for efficacy in down modulating chronic inflammation. Dr. Mansfield has documented success mentoring graduate students and seeks to expand her mentoring of D.V.M.s in mouse pathobiology.

描述（由申请人提供）：投资曼斯菲尔德博士的小鼠模型活动将导致在理解和治疗肠道病原体引起的肠道疾病和培养兽医进入研究领域的肠道疾病。曼斯菲尔德博士毕业于博士学位。 1990年在宾夕法尼亚大学的生物医学研究生研究计划，并于1994年在动物寄生虫研究所完成了博士后培训。目前，她的培训距离她有11年的历史，因此有资格担任中期研究员。她的培训和研究生涯花在开发人类和动物感染性肠道疾病的动物模型中。从1990 - 2003年开始，她致力于寻找自然发生的动物模型，用于弯曲杆菌的空肠和囊肿形成球球菌（Sarcococystis Neurona等），其长期目标将这些转换为小鼠模型。在2002 - 04年度，她成功地获得了资金来为这些病原体实施小鼠模型，因此，她将重点从这些人类和动物肠道疾病的大动物模型转移到了鼠模型中。最新资助的和未决的赠款对老鼠病理学的赠款证明了这一职业转变。同时，她要求缓解人口和动物健康诊断中心临床寄生虫科的行政职责。 Caseloads在她的领导下从1500到> 10,000/年迅速发展，以进行研究和指导的时间增加。曼斯菲尔德（Mansfield）博士寻求职业奖基金，以增强其在老鼠病理生物学方面的计划，尤其是在资助的NIH合同“密歇根州立大学微生物学研究部门：食品和水上综合研究网络”中从事项目。 These Career Award funds would enable new mouse models including, 1)"Murine models of C. jejuni colonization and enteritis" to determine mechanisms by which C. jejuni and other enteric bacteria stimulate chronic inflammation in the gut, and 2)"Worm mediated control of inflammatory Bowel Disease" to determine immunomodulatory properties of defined parasitic products from Trichuris on colonic inflammation (spontaneous and病原体介导）。这些小鼠模型将作为测试选定寄生虫及其分子的第一种模式，以减少调节慢性炎症。曼斯菲尔德（Mansfield）博士记录了成功指导研究生的成功，并试图扩大对鼠标病理学D.V.M.的指导。