Psychopathology in Pharmacotherapy of AUD/MDD Teens

描述（由申请人提供）：涉及青少年酒精使用障碍（AUD）研究的临床试验和临床指导远远落后于成人。这一面向患者研究的中期职业研究者奖提案描述了面向患者的研究、指导和职业发展的职业规划，涉及患有AUD和共病重抑郁症（MDD）的青少年临床试验领域。申请人之前已经证明了在涉及成人共病AUD/MDD的药物治疗研究方面的专业知识。该计划的职业发展部分将寻求扩展申请人的能力，以最佳方式进行和解释涉及青少年AUD人群的药物治疗研究。这一目标将通过加强申请人在发展精神病理学和特定的先进统计技术方面的背景来实现。这种培训将使申请人成为与这一重要但未充分研究的人群一起工作的受训者的更有效的导师。这项工作也将增强申请人对治疗期间共病AUD/MDD青少年抑郁症状的临床改善与酒精使用之间关系的认识。本次K24奖提出的临床研究与一项涉及氟西汀治疗青少年AUD/MDD共病的双盲、安慰剂对照研究（R01 AA13370）相关，该研究已进入第三个年头。

DESCRIPTION (provided by applicant): Clinical trials and clinical mentoring involving studies of adolescents with alcohol use disorders (AUD) lag considerably behind those for adults. This proposal for a Mid-Career Investigator Award in Patient-Oriented Research describes a career plan in patient-oriented research, mentorship, and career development in the area of clinical trials involving adolescents with AUD and comorbid major depression (MDD). The applicant has previously demonstrated expertise in conducting pharmacotherapy studies involving adults with comorbid AUD/MDD. The Career Development portion of this proposed award will seek to extend the applicant's ability to optimally conduct and interpret pharmacotherapy studies to those involving adolescent AUD populations. This goal would be accomplished by strengthening the applicant's background in developmental psychopathology and specified advanced statistical techniques. This training would make the applicant a more effective mentor for trainees working with this important but understudied population. This work would also enhance the applicant's knowledge of the relationship between clinical improvements in depressive symptoms and alcohol use among comorbid AUD/MDD adolescents during treatment. The clinical study proposed in this K24 award is associated with a double-blind, placebo-controlled study involving fluoxetine in adolescents with comorbid AUD/MDD (R01 AA13370), now in its third year. Research proposed in this application seeks to extend this funded work with adolescents by elucidating the nature of the relationship between improvement both in drinking and in depressive symptoms. This award would allow the applicant to curtail various clinical, administrative, and research duties in order to focus on adolescent populations with AUD. The largest part of the career plan is the mentoring of trainees in patient-oriented research involving adolescents with AUD. This will not only benefit the applicant's educational development, but will also address the paucity of researchers in this area.