Psychopathology in Pharmacotherapy of AUD/MDD Teens

描述（由申请人提供）：涉及酒精使用障碍（AUD）青少年研究的临床试验和临床指导远远落后于成人。这项以患者为导向的研究中期职业研究者奖的提案描述了在涉及青少年AUD和共病抑郁症（MDD）的临床试验领域以患者为导向的研究，指导和职业发展的职业计划。申请人之前已证明在进行涉及合并AUD/MDD的成人药物治疗研究方面具有专业知识。该奖项的职业发展部分将寻求扩大申请人的能力，以最佳方式进行和解释涉及青少年AUD人群的药物治疗研究。这一目标将通过加强申请人在发展心理病理学和指定的先进统计技术的背景来实现。这种培训将使申请人成为与这一重要但未得到充分研究的人口打交道的受训者的更有效的导师。这项工作还将提高申请人对治疗期间合并AUD/MDD青少年中抑郁症状临床改善与饮酒之间关系的认识。本次K24奖项中拟定的临床研究与一项涉及氟西汀治疗合并AUD/MDD青少年的双盲、安慰剂对照研究（R 01 AA 13370）相关，目前已进入第三年。 本申请中提出的研究旨在通过阐明饮酒和抑郁症状改善之间关系的性质，将这项资助的工作扩展到青少年。该奖项将允许申请人减少各种临床，行政和研究职责，以专注于青少年人群。职业计划的最大部分是指导学员进行以患者为导向的研究，涉及青少年AUD。这不仅有利于申请人的教育发展，而且还将解决这一领域研究人员缺乏的问题。

DESCRIPTION (provided by applicant): Clinical trials and clinical mentoring involving studies of adolescents with alcohol use disorders (AUD) lag considerably behind those for adults. This proposal for a Mid-Career Investigator Award in Patient-Oriented Research describes a career plan in patient-oriented research, mentorship, and career development in the area of clinical trials involving adolescents with AUD and comorbid major depression (MDD). The applicant has previously demonstrated expertise in conducting pharmacotherapy studies involving adults with comorbid AUD/MDD. The Career Development portion of this proposed award will seek to extend the applicant's ability to optimally conduct and interpret pharmacotherapy studies to those involving adolescent AUD populations. This goal would be accomplished by strengthening the applicant's background in developmental psychopathology and specified advanced statistical techniques. This training would make the applicant a more effective mentor for trainees working with this important but understudied population. This work would also enhance the applicant's knowledge of the relationship between clinical improvements in depressive symptoms and alcohol use among comorbid AUD/MDD adolescents during treatment. The clinical study proposed in this K24 award is associated with a double-blind, placebo-controlled study involving fluoxetine in adolescents with comorbid AUD/MDD (R01 AA13370), now in its third year. Research proposed in this application seeks to extend this funded work with adolescents by elucidating the nature of the relationship between improvement both in drinking and in depressive symptoms. This award would allow the applicant to curtail various clinical, administrative, and research duties in order to focus on adolescent populations with AUD. The largest part of the career plan is the mentoring of trainees in patient-oriented research involving adolescents with AUD. This will not only benefit the applicant's educational development, but will also address the paucity of researchers in this area.