Clinical Core

临床核心

• 批准号: 7813365
• 负责人: JACK R CORNELIUS
• 金额: $ 54.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7813365
• 关键词: 12 year old; Address; Adult; Age; Biochemical; Biological; Blood; Blood specimen; Child; Childhood; Clinical; Collaborations; Collection; Comorbidity; Data; Databases; Dental; Development; Diagnostic; Doctor of Medicine; Drug Formulations; Empirical Research; Ensure; Etiology; Evaluation; Event-Related Potentials; Faculty; Family; Family member; Fathers; Functional Magnetic Resonance Imaging; Genetic; Goals; Health; Health behavior; Home visitation; House Call; Interview; Laboratories; Master of Public Health; Measurement; Measures; Medical; Methods; Mothers; Nuclear Family; Outcome; Participant; Patient Self-Report; Policies; Procedures; Protocols documentation; Psychiatric Diagnosis; Publications; Regulation; Research; Research Ethics Committees; Role; Saliva; Sampling; Schedule; Science; Sex Behavior; Siblings; Skin; Specimen; Spouses; Staging; Stepparent; Substance Use Disorder; Suicide; United States National Institutes of Health; Universities; Urine; Variant; cohort; data acquisition; follow up assessment; follow-up; indexing; informant; member; mortality; neurocognitive test; proband; statistics; teacher

The Clinical Core is the operational hub of the Center. It is integral to collecting the data necessary for satisfying centerwide aims as well as the specific aims of each research module. The Clinical Core also conducts the psychiatric diagnostic evaluations of all members of the nuclear family (N= 775 families) consisting of the proband father, his spouse, and has biological and stepchildren. Step-parents are also diagnostically evaluated. In addition, this Core performs medical and dental examinations of the children and administers the research protocols to each family member, including collection of biological specimens (blood, saliva, skin, urine) for timely distribution to various laboratories. The Clinical Core ensures compliance with the University of Pittsburgh IRB, HIPPA, and NIH regulations. While primarily responsible for operational support of the Center's scientific activities, faculty in this Core are also integrally involved in empirical research. Accordingly, recent publications have focused on diverse topics, including the role of orodental health on SUD development, suicidality, sexual behavior and STD's, mortality, and health and psychiatric comorbidity.

临床核心是该中心的业务枢纽。它对于收集满足中心范围目标以及每个研究模块的具体目标所需的数据是不可或缺的。临床中心还对核心家庭（N= 775个家庭）的所有成员进行精神病诊断评估，核心家庭由先证者父亲、其配偶以及有生物学和继子女的人组成。继父母也进行诊断评估。此外，该中心还对儿童进行医疗和牙科检查，并向每个家庭成员执行研究方案，包括收集生物标本（血液、唾液、皮肤、尿液），及时分发给各实验室。临床核心确保符合匹兹堡大学IRB， HIPPA和NIH法规。虽然主要负责该中心的科学活动的业务支持，教师在这个核心也整体参与实证研究。因此，最近的出版物集中在不同的主题，包括口腔健康的作用SUD的发展，自杀，性行为和性病的，死亡率，健康和精神共病。