CLINICAL CORE

临床中心是中心的运营中心。因此，收集满足中心科学任务所需的数据以及实现每个模块的研究目标是不可或缺的。及时、准确和完整的数据收集是一项重要的高度优先的任务。在履行这一首要责任时，临床核心对所有受试者（先证者、配偶、子女）进行诊断确定，并监督所有受试者的实施

The Clinical Core is the operational hub of the Center. It is thus integral to collecting the data necessary for satisfying the Center's scientific mission as well as achieving the research goals of each module. Timely, accurate and complete data collection is an essential highly prioritized task. In fulfilling this overarching responsibility, the Clinical Core conducts the diagnostic ascertainment of all subjects (probands, spouses, children), oversees implementation of all the research protocols, and directs biological specimen collection and distribution of the samples to various laboratories. In addition, the Clinical Core exercises oversight of all Center human subject and data collection procedures pertinent to ensuring compliance with the University Pittsburgh IRB and NIH regulations.