Diabetes and Incontinence

描述(由申请人提供)： 珍妮特·S·布朗，医学博士，加州大学旧金山分校妇产科、生殖科学、泌尿学和流行病学教授。她是ORWH/NIDDK资助的加州大学旧金山分校女性下尿路功能专门研究中心、加州大学旧金山分校女性大陆中心和加州大学旧金山分校女性健康研究中心临床研究联谊会的主任。布朗博士也是加州大学旧金山分校临床与转化科学培训(CTST)项目的联席主任，主要负责初级教师的职业发展。加州大学旧金山分校的CTST包括NIH K30研究奖和路线图K12多学科职业发展奖，提供必要的培训系统，以提高临床和翻译科学家的数量、质量和跨学科技能。 这项拟议的研究旨在确定，在患有糖尿病前期和糖尿病的女性中，尿失禁的患病率和发生率按类型和严重程度划分，包括总体和按种族划分；与尿失禁相关的风险因素，特别是与糖尿病严重程度相关的因素(病程、治疗、血糖控制、存在微血管并发症，包括视网膜病变、肾病和神经病变)；以及包括血糖控制或体重减轻在内的干预措施是否可以预防或减轻糖尿病女性患者的尿失禁严重程度。将分析来自两项研究的问卷、实验室和结果数据，这两项研究包括糖耐量受损(糖尿病前期)和2型糖尿病女性，以及一项基于人群的队列研究，包括患有和不患有2型糖尿病的女性。她的长期研究目标是对糖尿病女性大小便失禁的预防和临床治疗做出有意义的贡献。 布朗博士得到了她所在部门、加州大学旧金山分校CTST项目、加州大学旧金山分校研究人员以及国内和国际临床和基础研究人员的热情支持，以追求她的研究目标。她是众多初级临床研究人员的高级导师，并将制定独特的加州大学旧金山分校综合导师计划，为临床和翻译研究人员培训下一代导师，并确保所有年轻研究人员都有适合其研究兴趣的导师。布朗博士的长期目标是将模范辅导项目的成功元素传播到其他学术中心。

DESCRIPTION (provided by applicant): Jeanette S. Brown, MD is Professor of Obstetrics Gynecology and Reproductive Sciences, Urology, & Epidemiology at the University of California, San Francisco (UCSF). She is director of the ORWH/NIDDK funded UCSF Specialized Center of Research on Lower Urinary Tract Function in Women, UCSF Women's Continence Center, and the UCSF Women's Health Research Center Fellowship in Clinical Research. Dr. Brown is also co-director of the UCSF Clinical & Translational Sciences Training (CTST) program with primary responsibility for junior faculty career development. The UCSF CTST includes the NIH K30 Research Award and the Roadmap K12 Multi-disciplinary Career Development Award providing the training systems that are necessary to enhance the number, quality, and across-disciplinary skills of clinical and translational scientists. The proposed research is designed to determine, among women with pre-diabetes and diabetes: prevalence and incidence of urinary incontinence by type and severity, both overall and by race; risk factors associated with incontinence, especially aspects of diabetes severity (duration, treatment, glycemic control, presence of microvascular complications including retinopathy, nephropathy and neuropathy) that are associated with greater risk or severity of urinary incontinence; and whether interventions including glycemic control or weight reduction prevent or reduce severity of urinary incontinence among women with diabetes. Questionnaire, laboratory, and outcome data from two studies that include women with impaired glucose tolerance (pre-diabetes) as well as type 2 diabetes, and from a population-based cohort study that includes women with and without type 2 diabetes will be analyzed. Her long-term research goal is to contribute meaningfully to the prevention and clinical management of incontinence in women with diabetes. Dr. Brown has the enthusiastic support of her department, the UCSF CTST program, UCSF investigators, as well as national and international clinical and basic investigators to pursue her research goals. She is a senior mentor to numerous junior clinical investigators and will develop a unique UCSF Comprehensive Mentoring Program to train the next generation of mentors for clinical and translational researchers and assure that all young researchers have mentors appropriate to their research interest. Dr. Brown's long-term goal is to disseminate the successful elements of the model mentoring program to other academic centers.