Diabetes and Incontinence

糖尿病和失禁

• 批准号: 7681328
• 负责人: JEANETTE S BROWN
• 金额: $ 17.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7681328
• 关键词: Age; Antioxidants; Award; Body Weight decreased; Body mass index; California; Clinical; Clinical Investigator; Clinical Management; Clinical Research; Clinical Skills; Cohort Studies; Complications of Diabetes Mellitus; Data; Diabetes Mellitus; Diabetic Angiopathies; Discipline of obstetrics; Early treatment; Ecology; Elements; Epidemiology; Ethnic Origin; Ethnic group; Faculty; Fellowship; Funding; Genitourinary system; Glucose; Glycosylated hemoglobin A; Goals; Gynecology; Health; Incidence; Incontinence; Insulin; International; Intervention; K-Series Research Career Programs; Kidney Diseases; Laboratories; Long-Term Effects; Low Prevalence; Lower urinary tract; Measures; Mediating; Mediator of activation protein; Mentors; Modeling; Natural History; Neuropathy; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Study; Oxidative Stress; Prediabetes syndrome; Prevalence; Prevention; Questionnaires; Race; Research; Research Personnel; Retinal Diseases; Risk; Risk Factors; SECTM1 gene; San Francisco; Science; Scientist; Severities; Specialized Center; System; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Urinary Incontinence; Urology; Woman; Women' s Health; blood glucose regulation; career development; design; diabetes prevention program; diabetic; follow-up; glycemic control; impaired glucose tolerance; improved; interest; intervention effect; lifestyle intervention; microbial; next generation; parity; population based; prevent; professor; programs; reproductive; treatment duration

DESCRIPTION (provided by applicant): Jeanette S. Brown, MD is Professor of Obstetrics Gynecology and Reproductive Sciences, Urology, & Epidemiology at the University of California, San Francisco (UCSF). She is director of the ORWH/NIDDK funded UCSF Specialized Center of Research on Lower Urinary Tract Function in Women, UCSF Women's Continence Center, and the UCSF Women's Health Research Center Fellowship in Clinical Research. Dr. Brown is also co-director of the UCSF Clinical & Translational Sciences Training (CTST) program with primary responsibility for junior faculty career development. The UCSF CTST includes the NIH K30 Research Award and the Roadmap K12 Multi-disciplinary Career Development Award providing the training systems that are necessary to enhance the number, quality, and across-disciplinary skills of clinical and translational scientists. The proposed research is designed to determine, among women with pre-diabetes and diabetes: prevalence and incidence of urinary incontinence by type and severity, both overall and by race; risk factors associated with incontinence, especially aspects of diabetes severity (duration, treatment, glycemic control, presence of microvascular complications including retinopathy, nephropathy and neuropathy) that are associated with greater risk or severity of urinary incontinence; and whether interventions including glycemic control or weight reduction prevent or reduce severity of urinary incontinence among women with diabetes. Questionnaire, laboratory, and outcome data from two studies that include women with impaired glucose tolerance (pre-diabetes) as well as type 2 diabetes, and from a population-based cohort study that includes women with and without type 2 diabetes will be analyzed. Her long-term research goal is to contribute meaningfully to the prevention and clinical management of incontinence in women with diabetes. Dr. Brown has the enthusiastic support of her department, the UCSF CTST program, UCSF investigators, as well as national and international clinical and basic investigators to pursue her research goals. She is a senior mentor to numerous junior clinical investigators and will develop a unique UCSF Comprehensive Mentoring Program to train the next generation of mentors for clinical and translational researchers and assure that all young researchers have mentors appropriate to their research interest. Dr. Brown's long-term goal is to disseminate the successful elements of the model mentoring program to other academic centers.

描述（由申请人提供）： 珍妮特·S布朗博士是加州大学旧金山弗朗西斯科（UCSF）的妇产科和生殖科学、泌尿学和流行病学教授。她是ORWH/NIDDK资助的UCSF女性下尿路功能专业研究中心，UCSF女性控制中心和UCSF女性健康研究中心临床研究奖学金的主任。布朗博士也是UCSF临床与转化科学培训（CTST）计划的联合主任，主要负责初级教师的职业发展。UCSF CTST包括NIH K30研究奖和路线图K12多学科职业发展奖，提供必要的培训系统，以提高临床和转化科学家的数量，质量和跨学科技能。 拟议的研究旨在确定糖尿病前期和糖尿病妇女的尿失禁类型和严重程度的患病率和发病率，包括总体和种族;与尿失禁相关的风险因素，尤其是糖尿病严重程度方面（持续时间、治疗、血糖控制、微血管并发症（包括视网膜病）的存在，肾病和神经病）与尿失禁的风险或严重程度更高相关;以及包括血糖控制或体重减轻在内的干预措施是否预防或降低糖尿病女性尿失禁的严重程度。将分析来自两项研究的问卷调查、实验室和结局数据，其中包括葡萄糖耐量受损（糖尿病前期）和2型糖尿病女性，以及来自一项基于人群的队列研究的问卷调查、实验室和结局数据，其中包括患有和不患有2型糖尿病的女性。她的长期研究目标是为糖尿病女性尿失禁的预防和临床管理做出有意义的贡献。 博士布朗有她的部门，UCSF CTST计划，UCSF研究人员，以及国家和国际临床和基础研究人员的热情支持，以追求她的研究目标。她是许多初级临床研究人员的高级导师，并将开发一个独特的UCSF综合导师计划，为临床和转化研究人员培养下一代导师，并确保所有年轻的研究人员都有适合他们研究兴趣的导师。布朗博士的长期目标是将示范指导计划的成功要素传播到其他学术中心。