ORWH: SCOR on Sex and Gender Factors Affecting Women's *

描述(由申请人提供)： 拟建的性别和性别因素影响女性健康的专门研究中心(SCOR)是在加州大学旧金山分校创建下尿路功能和尿失禁领域基础和临床研究的一流中心的独特机会。拟议的加州大学旧金山分校将提供组织结构，以进一步开发和支持基础和临床研究人员的多学科合作研究项目。拟建中心的重点将是扩大有关女性尿路、膀胱和盆底功能的基本知识；增进对尿失禁自然病史的了解；并为女性尿失禁新疗法的开发提供信息。这项SCOR的长期目标是： *促进关于女性下尿路结构、功能和功能障碍的创新性翻译研究的增长。 *确定对临床实践有影响的致病机制。 *通过动物模型和体外研究增加对下尿路生物学的了解。 *利用基础和临床研究，开发和评估治疗女性尿失禁的新的、创新的疗法。 *收集相关的人体标本进行分析。 为了实现我们对女性下尿路的创新转化研究的总体目标，加州大学旧金山分校拥有强大的机构支持、领导力和一支具有生产力记录的高级和初级调查人员队伍。SCOR将整合关于女性下尿路功能和大小便失禁的实验室和临床研究，并采用“从工作台到床边”的协作研究模式，以促进将科学成果直接转化为改善患者护理。

DESCRIPTION (provided by applicant): The proposed Specialized Centers of Research (SCOR) on Sex and Gender Factors affecting Women's Health is a unique opportunity to create a premier center in basic and clinical research at UCSF in the area of lower urinary tract function and urinary incontinence. The proposed UCSF SCOR will provide the organizational structure to further develop and support multi-disciplinary, collaborative research projects from both basic and clinical investigators. The focus of the proposed Center will be to expand basic knowledge about female urethral, bladder, and pelvic floor function; improve understanding of the natural history of incontinence; and provide information for the development of novel treatments for female urinary incontinence. The long term goals of this SCOR are to: * Foster the growth of innovative translational research on female lower urinary tract structure, function, and dysfunction. * Identify pathogenetic mechanisms with implications for clinical practice. * Increase understanding of lower urinary tract biology using animal models and in vitro studies. * Use basic and clinical research to develop and evaluate novel, innovative treatments for female urinary incontinence. * Create a collection of relevant human specimens for analysis. To achieve our overall goal of innovative translational research on the female lower urinary tract, the UCSF SCOR has strong institutional support, leadership and a cadre of senior and junior investigators with a record of productivity. The SCOR will integrate laboratory and clinical research on lower urinary tract function and incontinence in women with a "bench to bedside" collaborative research paradigm that will facilitate direct translation of scientific results to improved patient care.