ORWH: SCOR on Sex and Gender Factors Affecting Women's *

描述（由申请人提供）： 拟议中的关于影响妇女健康的性和性别因素的专业研究中心（SCOR）是一个独特的机会，可以在UCSF的下尿路功能和尿失禁领域建立一个基础和临床研究的首要中心。拟议的UCSF SCOR将提供组织结构，以进一步开发和支持基础和临床研究人员的多学科合作研究项目。拟建中心的重点将是扩大有关女性尿道，膀胱和骨盆底功能的基本知识;提高对尿失禁自然史的理解;并为女性尿失禁的新治疗方法的发展提供信息。这一战略合作伙伴关系的长期目标是： * 促进女性下尿路结构，功能和功能障碍的创新转化研究的增长。 * 确定发病机制与临床实践的影响。 * 使用动物模型和体外研究增加对下尿路生物学的理解。 * 使用基础和临床研究来开发和评估女性尿失禁的新型创新治疗方法。 * 创建一个相关的人体样本集进行分析。 为了实现我们对女性下泌尿道创新转化研究的总体目标，UCSF SCOR拥有强大的机构支持，领导和具有生产力记录的高级和初级研究人员队伍。SCOR将整合下尿路功能和女性尿失禁的实验室和临床研究，采用“从实验室到床边”的合作研究范式，促进科学结果直接转化为改善患者护理。

DESCRIPTION (provided by applicant): The proposed Specialized Centers of Research (SCOR) on Sex and Gender Factors affecting Women's Health is a unique opportunity to create a premier center in basic and clinical research at UCSF in the area of lower urinary tract function and urinary incontinence. The proposed UCSF SCOR will provide the organizational structure to further develop and support multi-disciplinary, collaborative research projects from both basic and clinical investigators. The focus of the proposed Center will be to expand basic knowledge about female urethral, bladder, and pelvic floor function; improve understanding of the natural history of incontinence; and provide information for the development of novel treatments for female urinary incontinence. The long term goals of this SCOR are to: * Foster the growth of innovative translational research on female lower urinary tract structure, function, and dysfunction. * Identify pathogenetic mechanisms with implications for clinical practice. * Increase understanding of lower urinary tract biology using animal models and in vitro studies. * Use basic and clinical research to develop and evaluate novel, innovative treatments for female urinary incontinence. * Create a collection of relevant human specimens for analysis. To achieve our overall goal of innovative translational research on the female lower urinary tract, the UCSF SCOR has strong institutional support, leadership and a cadre of senior and junior investigators with a record of productivity. The SCOR will integrate laboratory and clinical research on lower urinary tract function and incontinence in women with a "bench to bedside" collaborative research paradigm that will facilitate direct translation of scientific results to improved patient care.