SCOR ON LOWER URINARY TRACT FUNCTION IN WOMEN

女性下尿路功能的 SCOR

• 批准号: 7901951
• 负责人: JEANETTE S BROWN
• 金额: $ 6.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-29 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901951
• 关键词: SCOR; LOWER; URINARY; TRACT; FUNCTION

The proposed renewal of the UCSF SCOR on Lower Urinary Tract Function in Women is an exceptional opportunity to continue the unique and productive translational center. The UCSF SCOR 2002-2007 achieved our overriding goal of innovative translational research by enhancing the productivity of our basic and clinical investigators resulting in 41 published manuscripts and grant support through a U01, four ROl's, and a NIH Merit award. Catalyzing "Knowledge Synthesis" on lower urinary tract function in women, our research programs are actively contributing to improved patient care. For our SCOR renewal, we are building on strong leadership and senior scientists from many disciplines with a growing foundation of funded, successful research programs. The greatest strengths of our UCSF SCOR include the close proximity of internationally recognized laboratory and clinical researchers, the productive achievements of our current SCOR projects and effective translational research collaborations. The UCSF SCOR multidisciplinary, multi-institutional program proposes three new projects and continuation and expansion of the Biostatistics and Data Management and Administrative Cores, The 4 major areas of scientific integration and collaboration include: 1. Advancing novel treatments for stress incontinence: Characterizing adipose-derived stem cells for treatment; 2. Identifying mechanisms by which obesity, pre-diabetes, and diabetes cause incontinence: In a realistic type 2 diabetes rat model and prospective population-based ethnically diverse cohorts; 3. Exploring genetic risk factors for incontinence: Using our population-based DNA bank and gene expression in a unique incontinent rat model; 4. Understanding the effects of hormones and selective estrogen receptor modulators on incontinence: Including basic mechanism investigations and linkage to pharmacy records and use of phytoestrogens To achieve our overall goal of innovative translational research on the female lower urinary tract, the UCSF SCOR has strong institutional support, collaborations with UCSF senior scientists and other internationally recognized researchers, outstanding leadership and a cadre of senior and junior investigators with a record of excellent productivity. The UCSF SCOR will continue to accelerate the pace at which discoveries in basic science can serve the health of our patients and populations.

加州大学旧金山分校关于女性下尿路功能的SCOR更新建议是一个例外 延续独一无二且富有成效的翻译中心的机会。加州大学旧金山分校2002-2007年SCOR 通过提高我们的基础工作效率，实现了创新翻译研究的首要目标 和临床研究人员发表了41篇手稿，并通过U01，4个ROL， 以及美国国立卫生研究院荣誉奖。催化知识合成对女性下尿路功能的影响 研究项目正在积极地为改善患者护理做出贡献。对于我们的SCOR续订，我们正在建造 依靠强大的领导力和来自多个学科的资深科学家，以及越来越多的资金基础， 成功的研究项目。我们加州大学旧金山分校的最大优势包括 国际公认的实验室和临床研究人员，我们目前取得的丰硕成果 SCOR项目和有效的翻译研究协作。 加州大学旧金山分校的SCOR多学科、多机构计划提出了三个新项目和 生物统计和数据管理及行政核心的延续和扩大，4 科学整合和协作的主要领域包括： 1.发展治疗压力性尿失禁的新疗法： 用于治疗的脂肪来源干细胞的特征； 2.确定肥胖、糖尿病前期和糖尿病导致大小便失禁的机制： 在现实的2型糖尿病大鼠模型和基于预期人群的种族多样性队列中； 3.探索大小便失禁的遗传风险因素： 使用我们基于种群的DNA库和在一种独特的大小便失禁大鼠模型中的基因表达； 4.了解激素和选择性雌激素受体调节剂对大小便失禁的影响： 包括基本机制调查以及与药房记录和植物雌激素使用的联系 为了实现我们对女性下尿路的创新翻译研究的总体目标， 加州大学旧金山分校拥有强大的机构支持，与加州大学旧金山分校资深科学家和其他人合作 国际公认的研究人员、杰出的领导和一支高级和初级调查人员队伍 有着出色的生产力记录。加州大学旧金山分校将继续加快 基础科学的发现可以为我们的患者和人群的健康服务。