SCOR ON LOWER URINARY TRACT FUNCTION IN WOMEN

UCSF SCOR关于女性下尿路功能的拟议更新是继续独特和富有成效的翻译中心的绝佳机会。UCSF SCOR 2002-2007通过提高我们的基础和临床研究人员的生产力，实现了我们创新转化研究的首要目标，通过U 01，四个R 01和NIH Merit奖获得了41篇已发表的手稿和赠款支持。我们的研究项目促进了女性下尿路功能的“知识综合”，积极促进了患者护理的改善。对于我们的SCOR更新，我们正在建立强大的领导和来自许多学科的高级科学家，并为资助，成功的研究计划奠定了越来越大的基础。我们的UCSF SCOR的最大优势包括国际公认的实验室和临床研究人员的紧密联系，我们目前的SCOR项目的富有成效的成就和有效的转化研究合作。 UCSF SCOR多学科，多机构计划提出了三个新项目以及生物统计学和数据管理和行政核心的延续和扩展，科学整合和合作的4个主要领域包括： 1.推进压力性尿失禁的新疗法：脂肪源性干细胞治疗的特点; 2.肥胖、糖尿病前期和糖尿病导致尿失禁的机制的识别：在现实的2型糖尿病大鼠模型和基于人群的前瞻性种族多样性队列中; 3.探索失禁的遗传风险因素：在一个独特的失禁大鼠模型中使用我们基于人群的DNA库和基因表达; 4.了解激素和选择性雌激素受体调节剂对尿失禁的影响：包括基本机制研究和与药房记录和植物雌激素使用的联系 为了实现我们对女性下泌尿道创新转化研究的总体目标，UCSF SCOR拥有强大的机构支持，与UCSF高级科学家和其他国际公认的研究人员合作，杰出的领导力以及具有卓越生产力记录的高级和初级研究人员的干部。UCSF SCOR将继续加快基础科学发现的步伐，为我们的患者和人群的健康服务。

The proposed renewal of the UCSF SCOR on Lower Urinary Tract Function in Women is an exceptional opportunity to continue the unique and productive translational center. The UCSF SCOR 2002-2007 achieved our overriding goal of innovative translational research by enhancing the productivity of our basic and clinical investigators resulting in 41 published manuscripts and grant support through a U01, four R01s, and a NIH Merit award. Catalyzing "Knowledge Synthesis" on lower urinary tract function in women, our research programs are actively contributing to improved patient care. For our SCOR renewal, we are building on strong leadership and senior scientists from many disciplines with a growing foundation of funded, successful research programs. The greatest strengths of our UCSF SCOR include the close proximity of internationally recognized laboratory and clinical researchers, the productive achievements of our current SCOR projects and effective translational research collaborations. The UCSF SCOR multidisciplinary, multi-institutional program proposes three new projects and continuation and expansion of the Biostatistics and Data Management and Administrative Cores, The 4 major areas of scientific integration and collaboration include: 1. Advancing novel treatments for stress incontinence: Characterizing adipose-derived stem cells for treatment; 2. Identifying mechanisms by which obesity, pre-diabetes, and diabetes cause incontinence: In a realistic type 2 diabetes rat model and prospective population-based ethnically diverse cohorts; 3. Exploring genetic risk factors for incontinence: Using our population-based DNA bank and gene expression in a unique incontinent rat model; 4. Understanding the effects of hormones and selective estrogen receptor modulators on incontinence: Including basic mechanism investigations and linkage to pharmacy records and use of phytoestrogens To achieve our overall goal of innovative translational research on the female lower urinary tract, the UCSF SCOR has strong institutional support, collaborations with UCSF senior scientists and other internationally recognized researchers, outstanding leadership and a cadre of senior and junior investigators with a record of excellent productivity. The UCSF SCOR will continue to accelerate the pace at which discoveries in basic science can serve the health of our patients and populations.