GENETICS OF KIDNEYS IN DIABETES STUDY

糖尿病研究中的肾脏遗传学

• 批准号: 7605966
• 负责人: MICHAEL S MAUER
• 金额: $ 2.17万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605966
• 关键词: Academic Medical Centers; Blood; Boston; Canada; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Data; Development; Diabetes Mellitus; Diabetic Nephropathy; Discipline of Nursing; Family; Funding; Genes; Genetic; Genetic Predisposition to Disease; Grant; Institution; Insulin-Dependent Diabetes Mellitus; Kidney; Kidney Diseases; Measures; Minor; Numbers; Parents; Participant; Patients; Predisposition; Process; Recruitment Activity; Research; Research Personnel; Resources; Sampling; Site; Source; Time; United States; United States National Institutes of Health; Universities; Urine; Washington; base; clinical research site

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GoKinD Study is a collaborative effort between the George Washington University, DC; Joslin Diabetes Center, Boston, MA; and 30 additional sites throughout the United States and Canada to establish a respository of DNA and clinical information from a large number of unrelated patients with type 1 diabetes in order to facilitate studies from a large number of unrelated patients with type 1 diabetes in order to facilitate studies into the genetic basis of diabetic nephropathy. Strong evidence from scientific data and family data exists to support that there is a genetic susceptibility for people to develop kidney disease due to diabetes. Recent developments in genetics have made it possible to search for the genes responsible for this susceptibility. In total, the project will recruit over 4,300 participants. About 2,000 people with type 1 diabetes and about half of that number's parents. We ask the GCRC to be the clinical site for participants who come to Fairview-University Medical Center. The GCRC would be responsible for nursing time in collecting blood, random urine samples, and physical measures. In addition, minor processing of blood would be needed. All samples would be transported by our research staff.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 GoKinD 研究是乔治华盛顿大学、哥伦比亚特区和乔治华盛顿大学之间的合作项目；乔斯林糖尿病中心，波士顿，马萨诸塞州；以及遍布美国和加拿大的另外 30 个站点，建立大量无关 1 型糖尿病患者的 DNA 和临床信息存储库，以便于对大量无关 1 型糖尿病患者进行研究，从而促进对糖尿病肾病遗传基础的研究。 来自科学数据和家庭数据的有力证据表明，人们存在因糖尿病而罹患肾病的遗传易感性。 遗传学的最新发展使得寻找导致这种易感性的基因成为可能。 该项目总共将招募超过 4,300 名参与者。 大约有 2,000 名 1 型糖尿病患者，其中大约一半是其父母。 我们要求 GCRC 成为来到 Fairview 大学医学中心的参与者的临床地点。 GCRC 将负责采集血液、随机尿液样本和身体测量的护理时间。 此外，还需要对血液进行少量处理。 所有样品将由我们的研究人员运输。