STRUCTURAL FUNCTIONAL RELATIONSHIPS IN DIABETIC NEPHROPATHY

糖尿病肾病的结构功能关系

• 批准号: 7605947
• 负责人: MICHAEL S MAUER
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605947
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Diabetic Nephropathy; Electrons; Funding; Grant; Hypertension; Institution; Lesion; Light; Microalbuminuria; Microscopic; Pancreas; Proteinuria; Protocols documentation; Purpose; Research; Research Personnel; Resources; Source; Transplantation; United States National Institutes of Health; morphometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has two major purposes. First, we are examining structural-functional relationships in diabetic nephropathy using quantitative light and electron microscopic morphometry to determine the structural substrates for microalbuminuria, proteinuria, hypertension and declining GFR. Secondly, we are examining the effects of pancreas transplant on the established lesions of diabetic nephropathy at five, ten, and fifteen year intervals after successful transplantation.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该协议有两个主要目的。 首先，我们正在研究糖尿病肾病的结构-功能关系，使用定量光镜和电镜形态测定，以确定微量白蛋白尿，蛋白尿，高血压和GFR下降的结构基板。 其次，我们正在研究胰腺移植对糖尿病肾病的影响，在成功移植后的5年，10年和15年的时间间隔。