RENIN ANGIOTENSIN SYSTEM STUDY (RASS)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 这是一项随机、对照、双盲、三组、为期5年的试验，在肾小球滤过率（GFR）正常的正常白蛋白尿、血压正常的IDDM患者中，通过形态计量学测定血管紧张素转换酶抑制剂（依那普利）、血管紧张素II受体阻断剂（氯沙坦）和安慰剂预防糖尿病早期肾脏结构变化。 目的是在三个中心（明尼苏达大学、麦吉尔大学和多伦多大学）招募285例患者，并比较三组的主要终点系膜扩张率，系膜扩张率是在相隔5年进行的两次肾活检中测量的。 间隔测量将包括尿白蛋白排泄、GFR和GFR。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized, controlled, double-blinded, three armed, 5 year trial of angiotensin converting enzyme inhibition (Enalapril), angiotensin II receptor blockade (Losartan), and placebo in prevention of the early renal structural changes of diabetes measured by morphometry in normoalbuminuric, normotensive, IDDM patients with normal glomerular filtration rate (GFR). The aim is to recruit 285 patients in three centers (U of Minnesota, McGill University and the University of Toronto) and to compare the three groups for the primary endpoint of the rate of mesangial expansion as measured in two renal biopsies performed five years apart. Interval measures will include urinary albumin excretion, GFR and glycemia.