RENIN ANGIOTENSIN SYSTEM STUDY (RASS)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项随机、对照、双盲、三组、为期5年的血管紧张素转换酶抑制剂(Enalapril)、血管紧张素II受体阻滞剂(Losartan)和安慰剂预防糖尿病早期肾脏结构改变的试验，通过形态计量学方法在正常白蛋白尿、正常血压、肾小球滤过率(GFR)正常的IDDM患者中进行测量。目的是在三个中心(明尼苏达大学、麦吉尔大学和多伦多大学)招募285名患者，并比较这三组人在两次相隔五年的肾活检中测量的系膜扩张率的主要终点。间隔测量将包括尿白蛋白排泄、肾小球滤过率和血糖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized, controlled, double-blinded, three armed, 5 year trial of angiotensin converting enzyme inhibition (Enalapril), angiotensin II receptor blockade (Losartan), and placebo in prevention of the early renal structural changes of diabetes measured by morphometry in normoalbuminuric, normotensive, IDDM patients with normal glomerular filtration rate (GFR). The aim is to recruit 285 patients in three centers (U of Minnesota, McGill University and the University of Toronto) and to compare the three groups for the primary endpoint of the rate of mesangial expansion as measured in two renal biopsies performed five years apart. Interval measures will include urinary albumin excretion, GFR and glycemia.